Silver Nanoparticles Loaded With Oleuropein Alleviates LPS‐Induced Acute Lung Injury by Modulating the TLR4/P2X7 Receptor‐Mediated Inflammation and Apoptosis in Rats
Yazarlar (5)
Dr. Öğr. Üyesi Seda Yakut Burdur Mehmet Akif Ersoy Üniversitesi, Türkiye
Doç. Dr. Volkan GELEN Kafkas Üniversitesi, Türkiye
Doç. Dr. Hülya Kara Atatürk Üniversitesi, Türkiye
Doç. Dr. Seçkin Özkanlar Atatürk Üniversitesi, Türkiye
Doç. Dr. Ali YEŞİLDAĞ Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Environmental Toxicology (Q1) | ||
| Dergi ISSN | 1520-4081 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 07-2024 |
| Cilt / Sayı / Sayfa | 39 / 11 / 4960–4973 | DOI | 10.1002/tox.24369 |
| Makale Linki | https://doi.org/10.1002/tox.24369 | ||
| UAK Araştırma Alanları |
Fen Bilimleri ve Matematik
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| Özet |
| Toll‐like receptor 4 (TLR‐4) ligands were initially shown to be the source of lipopolysaccharide (LPS), a gram‐negative bacterium's cell wall immunostimulatory component. Oxidative stress, apoptosis, and inflammation are all potential effects of LPS treatment on the lungs. By triggering oxidative stress and inflammation, these negative effects could be avoided. Robust flavonoid oleuropein (OLE) exhibits anti‐inflammatory, antiproliferative, and antioxidative properties. A nanodelivery system could improve its low bioavailability, making it more effective and useful in treating chronic human ailments. This study evaluates the effects of AgNP‐loaded OLE on LPS‐induced lung injury in rats in terms of TLR4/P2X7 receptor‐mediated inflammation and apoptosis. Forty‐eight male albino rats were randomly divided into eight groups. Drugs were administered to the groups in the doses specified as follows: Control, LPS (8 … |
| Anahtar Kelimeler |
| apoptosis | inflammation | oleuropein | oxidative stress | silver nanoparticles |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 16 |
| Google Scholar | 17 |