Combating oxidative stress and inflammation in gentamicin-induced nephrotoxicity using hydrogen-rich water
Yazarlar (7)
Doç. Dr. Mustafa MAKAV Kafkas Üniversitesi, Türkiye
Prof. Dr. Serpil DAĞ Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ayfer YILDIZ UYSAL Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Lale BAŞER Kafkas Üniversitesi, Türkiye
Tyler W. Lebaron
Durıed Alwazeer
Türkiye
Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | TISSUE & CELL (Q1) | ||
| Dergi ISSN | 0040-8166 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2024 |
| Cilt / Sayı / Sayfa | 91 / 0 / 102604– | DOI | 10.1016/j.tice.2024.102604 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0040816624003057 | ||
| UAK Araştırma Alanları |
Veteriner Patolojisi
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| Özet |
| Gentamicin-induced nephrotoxicity primarily results from renal inflammatory cascades and increased oxidative stress. This study aims to examine the effects of hydrogen-rich water (HRW) on gentamicin-induced renal damage in rats. Thirty-two rats were equally divided into four groups, including control (no treatment), hydrogen, gentamicin, and gentamicin+hydrogen. At the end of one week, all animals were euthanized following ethical rules, and blood and tissue samples were analyzed for examining Malondialdehyde (MDA), glutathione (GSH), Tumor Necrosis Factor-Alfa (TNF-α), Tumor Necrosis Factor-Beta (TNF-β), Interleukin 6 (IL-6), endoglin, endocan, urea, creatinine, Na, and K parameters. Levels of 8-Hydroxyguanosine (8-OHdG), MDA, and Bax were immunohistochemically analyzed. Data showed that while MDA (control P<0.0001, HP<0.0001, Genta+HP<0.0007), TNF-α (control P<0.0002, HP<0.0040, Genta+HP<0.0381), IL-6 (control P<0.0044, HP<0.0070, Genta+HP<0.0109), endocan (control P<0.0460, HP<0.0286, Genta+HP<0.0452), and endoglin (control P<0.0131, HP<0.0164, Genta+HP<0.0397), urea (control P<0.0024, HP<0.0001, Genta+HP<0.0180), and creatinine parameters (control P<0.0017, HP<0.0178, Genta+HP<0.0011) increased in the gentamicin group compared to the other groups, a decrease in these parameters was observed in the gentamicin+hydrogen group compared to the gentamicin group. The Genta group had greater levels of TNF-β than the control (P<0.0042) and H2 groups (P<0.0268). GSH content was higher in the hydrogen group compared to the gentamicin group. Immunohistochemically, 8-OHdG, MDA, and Bax expressions increased in the gentamicin group compared to the control group, whereas they decreased in the gentamicin+hydrogen group compared to the gentamicin group. Hydrogen may be an alternative treatment for oxidative stress-induced nephrotoxicity. |
| Anahtar Kelimeler |
| Molecular hydrogen | Hydrogen-rich water | Nephrotoxicity | Gentamicin | Inflammation | Oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 16 |