Targeting Lung Cancer With Carvacrol‐Triazole‐Arylidene Hydrazide Hybrids: In Vitro and In Silico Cytotoxicity Assessments
Yazarlar (7)
Arş. Gör. Furkan Çakır Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Arş. Gör. Şeyma Ateşoğlu Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Zeynep Ravza Müderrisoğlu Bezmiâlem Vakıf Üniversitesi, Türkiye
Firdevs Demirel Istanbul Üniversitesi, Türkiye
Prof. Dr. Fahri Akbaş Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
Doç. Dr. Halil Şenol Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Chemistry and Biodiversity (Q3) | ||
| Dergi ISSN | 1612-1872 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2025 |
| Cilt / Sayı / Sayfa | 22 / 6 / 1–22 | DOI | 10.1002/cbdv.202402963 |
| Makale Linki | https://doi.org/10.1002/cbdv.202402963 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| In this study, a series of 16 arylidene hydrazide derivatives (7a–7p), hybridized with the natural product carvacrol, were successfully synthesized starting from anthranilic acid methyl ester. The cytotoxic effects of these compounds were examined against two different cell lines, A549 and BEAS‐2B. Additionally, in silico studies were conducted to investigate the ligand–protein binding modes and their stabilities. Lastly, the predicted absorption, distribution, metabolism, and excretion (ADME) properties were also explored. The compounds’ structures were confirmed through meticulous NMR and MS spectral analyses. Biological assays indicated notable cytotoxic effects against human lung cancer (A549) and non‐tumorigenic lung epithelial (BEAS‐2B) cell lines, with compounds 7j, 7k, and 7l demonstrating high selectivity indices (SIs) and low IC50 values against A549 cells, signifying potent selective anticancer … |
| Anahtar Kelimeler |
| anticancer | arylidene hydrazide | carvacrol | molecular docking | molecular dynamics |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 15 |
| Scopus | 13 |
| Google Scholar | 14 |