Expression of a splicing isoform of MAIR-V (CD300LF), an inhibitory immunoglobulin-like receptor on myeloid cells
Yazarlar (3)
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | HYBRIDOMA | ||
| Dergi ISSN | 1554-0014 | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2008 |
| Cilt / Sayı / Sayfa | 27 / 1 / 59–61 | DOI | 10.1089/hyb.2007.0534 |
| Özet |
| The myeloid-associated immunoglobulin-like receptor (MAIR) family consists of nine activating or inhibitory cell surface receptors preferentially expressed on myeloid cells, which are encoded by the genes in a small cluster on mouse chromosome 11. MAIR-Va, one of the inhibitory receptors in the family, has a splicing isoform, MAIR-Vb. However, the expression profile of MAIR-Va and MAIR-Vb has remained unclear. Here, we generated three monoclonal antibodies (MAb)-TX70, TX71, and TX73-against MAIR-V. TX70 and TX73 MAbs recognized both MAIR-Va and MAIR-Vb. In contrast, TX71 recognized MAIR-Va, but not MAIR-Vb. Western blot analyses by using these MAbs revealed that MAIR-Va and MAIR-Vb were almost equally expressed in the spleen cells and peritoneal exudate cells. Thus, these MAbs are useful for analyses of molecular and functional characteristics of MAIR-Va and MAIR-Vb. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 5 |