Activation of neutrophils by a novel triggering immunoglobulin-like receptor MAIR-IV
Yazarlar (8)
Satoko Tahara-Hanaoka
Akira Shibuya
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | MOLECULAR IMMUNOLOGY | ||
| Dergi ISSN | 0161-5890 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2008 |
| Cilt / Sayı / Sayfa | 45 / 1 / 289–294 | DOI | 10.1016/j.molimm.2007.04.011 |
| Özet |
| Neutrophils play a central role in host defenses against infectious microbial pathogens. However, molecular basis for their triggering signals has been incompletely understood. Here, we show molecular and functional characteristics of myeloid-associated immunoglobulin-like receptor (MAIR)-IV. MAIR-IV was preferentially expressed on neutrophils in the peripheral blood, bone marrow, peritoneal cavity and spleen. MAIR-IV physically associates with immunoreceptor tyrosine based activating motif (ITAM)-bearing adaptor FcRgamma chain. Cross-linking MAIR-IV with anti-MAIR-IV monoclonal antibody significantly induced secretion of proinflammatory cytokines TNF-alpha and IL-6 from neutrophils. Thus, MAIR-IV may regulate activation of neutrophils and play an important role for innate immunity. |
| Anahtar Kelimeler |
| Neutrophils | MAIR-IV | CLM5 | FcR gamma chain | innate immunity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 19 |