| Yazarlar (11) |
Veysel Ozan Tanik
|
|
Evliya Akdeniz
|
|
Tufan Cinar
|
|
Baris Simsek
|
|
Duygu Inan
|
|
Ahmet Kivrak
|
Doç. Dr. Yavuz KARABAĞ
Kafkas Üniversitesi, Türkiye |
|
Metin Cagdas
|
|
Kamuran Kalkan
|
|
Can Yucel Karabay
|
|
Bulent Ozlek
|
| Özet |
| : In this study, we aimed to investigate the prognostic value of the C-reactive protein to albumin ratio (CAR) for all-cause mortality in patients with chronic heart failure with reduced ejection fraction (HFrEF). : In total, 404 chronic HFrEF patients were included in this observational and retrospective study. The CAR value of each patient included in this analysis was calculated. We stratified the study population into tertiles (T1, T2, and T3) according to CAR values. The primary outcome of the analysis was to determine all-cause mortality. : The median follow-up period in our study was 30 months. In the follow-up, 162 (40%) patients died. The median value of CAR was higher in patients who did not survive during the follow-up [6.7 (IQR = 1.6-20.4) vs. 0.6 (IQR = 0.1-2.6), < 0.001]. In addition, patients in the T3 tertile (patients with the highest CAR) had a higher rate of all-cause mortality [n = 90 cases (66.2%), < 0.001]. Multivariate Cox regression analysis revealed that CAR was an independent predictor of mortality in patients with HFrEF (hazard ratio: 1.852, 95% confidence interval: 1.124-2.581, = 0.005). In a receiver operating characteristic curve analysis, the optimal cut-off value of CAR was >2.78, with a sensitivity of 66.7% and specificity of 76%. Furthermore, older age, elevated N-terminal pro-brain natriuretic peptide levels, and absence of a cardiac device were also independently associated with all-cause death in HFrEF patients after 2.5 years of follow-up. : The present study revealed that CAR independently predicts long-term mortality in chronic HFrEF patients. CAR may be used to predict mortality among these patients as a simple and easily obtainable inflammatory marker. |
| Anahtar Kelimeler |
| albumin | C-reactive protein | heart failure with reduced ejection fraction | mortality |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | MEDICINA-LITHUANIA |
| Dergi ISSN | 1010-660X |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2024 |
| Cilt No | 60 |
| Sayı | 3 |
| Doi Numarası | 10.3390/medicina60030441 |
| Atıf Sayıları | |
| WoS | 2 |
