| Yazarlar (6) |
Dr. Öğr. Üyesi Mehmet EZER
Kafkas Üniversitesi, Türkiye |
Engin Doğantekin
Antalya Training and Research Hospital, Türkiye |
|
Muzaffer Çaydere
Ankara Numune Education and Research Hospital, Turkey |
|
Aykut Koç
Siirt Training and Research Hospital, Türkiye |
|
Çağrı Öktem
Ankara Numune Education and Research Hospital, Turkey |
|
Sema Hücümenoğlu
Ankara Numune Education and Research Hospital, Turkey |
| Özet |
| Objective: This study aimed to evaluate the effects of two absorbable hemostatic agents, oxidized regenerated cellulose (ORC) and gelatin sponge, on wound healing in a rat model of penile fracture. Materials and methods: A total of 32 Wistar albino rats were divided into four groups: Control (C), Primary Suturing (PS), ORC, and Gelatin Sponge (GS). A penile fracture model was created in all rats, and wound healing was assessed histopathologically after two weeks. Key parameters assessed included primary healing, fibrosis, inflammation, and cavernous tissue healing. Results: The ORC group showed significantly higher primary healing rates (100%) compared to the other groups (p < 0.01). Fibrosis was more common in the GS group (87.5%), whereas no fibrosis was observed in the ORC group (p < 0.01). In terms of cavernous tissue healing, the group treated with the ORC absorbable hemostatic agent demonstrated significantly higher healing rates compared to the control group (p = 0.000). No significant differences were observed between groups regarding inflammation. Conclusion: ORC absorbable hemostatic agents significantly promote primary wound healing and reduce fibrosis in an experimental penile fracture model, whereas the gelatin sponge was associated with increased fibrosis and did not improve healing. These findings suggest that ORC may have potential clinical applications in penile fracture repair. Further clinical studies are necessary to validate these results. |
| Anahtar Kelimeler |
| Absorbable hemostatic gelatin sponge | Oxidized regenerated cellulose absorbable hemostat | Penil fracture | Spongostan | Surgicel |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | BMC Urology |
| Dergi ISSN | 1471-2490 |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2025 |
| Cilt No | 25 |
| Sayı | 1 |
| Doi Numarası | 10.1186/s12894-025-01697-8 |
| Atıf Sayıları |
