Assessment of chemical composition and in vitro and in silico anticarcinogenic activity of bee bread samples from Eastern Anatolia (Kars)
Yazarlar (3)
Dr. Öğr. Üyesi Güven GÜLBAZ Kafkas Üniversitesi, Türkiye
Doç. Dr. Giray Buğra AKBABA Kafkas Üniversitesi, Türkiye
Doç. Dr. Füreya Elif ÖZTÜRKKAN Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | European Food Research and Technology (Q2) | ||
| Dergi ISSN | 1438-2377 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2025 |
| Cilt / Sayı / Sayfa | 251 / 5 / 899–914 | DOI | 10.1007/s00217-025-04679-0 |
| Makale Linki | https://doi.org/10.1007/s00217-025-04679-0 | ||
| UAK Araştırma Alanları |
Anorganik Kimya
Spektroskopi
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| Özet |
| In this study, aqueous extracts of bee bread samples collected from five different regions in Eastern Anatolia (Kars, Turkey) were obtained by ultrasonic wave-assisted extraction method. Moisture, ash, acidity and pH values of bee bread samples were measured. Phenolic components of aqueous extracts were determined by LC-HRMS method. The cytotoxicity of these extracts on colon (DLD-1), breast (MCF-7), cervix (HeLa) and prostate cancer (PC-3) cells was determined by the MTT method. The interactions of genistein, naringenin and vitamin C, which are major components of the extracts, with important cancer targets such as human thymidylate synthase, c-MYC transcription factor, cyclin-dependent kinase and androgen receptor prostate cancer targets were investigated by Molecular Docking method. According to the findings, all extracts caused higher cytotoxicity on MCF-7 cancer cells compared to other cell … |
| Anahtar Kelimeler |
| Anticarcinogenic activity | Bee bread | Chemical composition | Molecular Docking |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 3 |