| Yazarlar (6) |
Dr. Öğr. Üyesi Mehmet EZER
Kafkas Üniversitesi, Türkiye |
Melek Öztürkler
Kafkas Üniversitesi, Türkiye |
|
Kezban Yıldız-Dalgınlı
Kafkas Üniversitesi, Türkiye |
|
Emine Atakişi
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye |
|
Hatice Beşeren-Havadar
Kafkas Üniversitesi, Türkiye |
|
Onur Atakişi
Kafkas Üniversitesi, Türkiye |
| Özet |
| Objective(s): This study aimed to evaluate the protective effects of shilajit on 5-fluorouracil (5-FU)-induced nephrotoxicity in a rat model. Materials and Methods: Twenty male Sprague Dawley rats were divided into four groups: Control, 5-FU, shilajit, and 5-FU + shilajit. 5-FU was administered intraperitoneally at 200 mg/kg, while shilajit was given orally at 200 mg/kg. Kidney tissues were analyzed for oxidative stress markers, protein expression (SIRT2, SIRT3, β-catenin, E-cadherin, and caspase-3), and histopathological changes. Results: 5-FU significantly increased oxidative stress parameters and kidney damage markers. Shilajit co-administration with 5-FU reduced oxidative stress and increased anti-oxidant status and SIRT2, SIRT3, and cell adhesion protein expression. Histopathological evaluation showed reduced renal damage in the shilajit + 5-FU group compared to the 5-FU group. Conclusion: Shilajit exhibited significant protective effects against 5-FU-induced nephrotoxicity, improving oxidative parameters, protein expression, and kidney histopathology. Further studies are needed to elucidate its molecular mechanism and therapeutic potential. |
| Anahtar Kelimeler |
| Caspase 3 | Fluorouracil | Nephrotoxicity | Plant | Resins | Sirtuin 2 | Sirtuin 3 |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Iranian Journal of Basic Medical Sciences |
| Dergi ISSN | 2008-3866 Wos Dergi Scopus Dergi |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2025 |
| Cilt No | 28 |
| Sayı | 5 |
| Sayfalar | 565 / 574 |
| Doi Numarası | 10.22038/ijbms.2025.80989.17525 |
| Atıf Sayıları |
