Investigation of the molecular and cellular effects of Shilajit on 5-fluorouracil (5-FU)-induced nephrotoxicity in rats
Yazarlar (6)
Dr. Öğr. Üyesi Mehmet EZER Kafkas Üniversitesi, Türkiye
Melek Öztürkler
Kafkas Üniversitesi, Türkiye
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Kezban YILDIZ DALGINLI Kafkas Üniversitesi, Türkiye
Prof. Dr. Emine ATAKİŞİ Kafkas Üniversitesi, Türkiye
Hatice Beşeren Havadar
Kafkas Üniversitesi, Türkiye
Kafkas Üniversitesi, Türkiye
Prof. Dr. Onur ATAKİŞİ Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Iranian Journal of Basic Medical Sciences (Q2) | ||
| Dergi ISSN | 2008-3866 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2025 |
| Cilt / Sayı / Sayfa | 28 / 5 / 565–574 | DOI | 10.22038/ijbms.2025.80989.17525 |
| Makale Linki | https://ijbms.mums.ac.ir/issue_2685_2750.html | ||
| Özet |
| Objective(s): This study aimed to evaluate the protective effects of shilajit on 5-fluorouracil (5-FU)-induced nephrotoxicity in a rat model. Materials and Methods Twenty male Sprague Dawley rats were divided into four groups: Control, 5-FU, shilajit, and 5-FU + shilajit. 5-FU was administered intraperitoneally at 200 mg/kg, while shilajit was given orally at 200 mg/kg. Kidney tissues were analyzed for oxidative stress markers, protein expression (SIRT2, SIRT3, β-catenin, E-cadherin, and caspase-3), and histopathological changes. Results 5-FU significantly increased oxidative stress parameters and kidney damage markers. Shilajit co-administration with 5-FU reduced oxidative stress and increased anti-oxidant status and SIRT2, SIRT3, and cell adhesion protein expression. Histopathological evaluation showed reduced renal damage in the shilajit + 5-FU group compared to the 5-FU group. Conclusion Shilajit … |
| Anahtar Kelimeler |
| Caspase 3 | Fluorouracil | Nephrotoxicity | Plant | Resins | Sirtuin 2 | Sirtuin 3 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |
| Web of Science | 1 |