| Yazarlar (5) |
Turgut Dolanbay
Malatya Turgut Ozal University, Turkey |
Doç. Dr. Mustafa MAKAV
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Hüseyin Fatih GÜL
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Emin KARAKURT
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Fikret BEKTAŞOĞLU
Kafkas Üniversitesi, Türkiye |
| Özet |
| Objectives: The present study identifies the level changes of markers (Apelin, Elabela, Meteorin, ALT, AST, GGT) in the liver after acute intake of high-dose paracetamol and their role in determining liver damage. Methods: The rats were categorized into two groups (Control and Toxication), each consisting of seven rats. Apelin, Elabela, Meteorin, ALT, AST and GGT levels were determined in liver tissue. The levels of Apelin, Elabela, and Meteorin in liver tissue homogenate were assessed following the kit procedure, utilizing commercial enzyme-linked immunosorbent assay. ALT, AST and GGT analyzes were performed from liver tissue homogenate with Erba colorimetric kit according to the kit procedure. It was also evaluated histopathologically from liver tissue. Results: Looking at the findings, a significant decrease was determined in the Elabela and Meteorin data in the Apap group compared to the control group. In the Apelin data, a statistical increase was observed in the Apap group compared to the control group. A significant increase in ALT analysis was detected in the APAP group compared to the control group. Considering GGT and AST data, a statistical increase was detected in the APAP group compared to the control group.While Bax, Bcl-2 and iNOS immunoreactivity was not observed in the control group, a yellowish-brown positive reaction was detected in the cytoplasm of degenerated and necrotic hepatocytes, especially around the vena centralis, in the paracetamol group. Conclusions: As a result, it is thought that Apelin, it is thought that Apelin, Elabela and Meteorin markers may be decisive markers in determining toxicity in liver damage. |
| Anahtar Kelimeler |
| APAP | apelin | bax | bcl-2 | elabela | meteorin |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Turkish Journal of Biochemistry |
| Dergi ISSN | 0250-4685 |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2025 |
| Sayı | 1 |
| Doi Numarası | 10.1515/tjb-2024-0045 |
| Atıf Sayıları |
