| Yazarlar (12) |
Dr. Öğr. Üyesi Serdar YİĞİT
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Şakir AKGÜN
Türkiye |
Dr. Öğr. Üyesi İsa YEŞİLYURT
Türkiye |
Dr. Öğr. Üyesi Soner BİTİKTAŞ
Türkiye |
Ergin Taşkın
Türkiye |
|
Ali Alper Kahraman
|
|
Muhammed Yayla
Türkiye |
Doç. Dr. Pınar AKSU KILIÇLE
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Seyit Ali BİNGÖL
Türkiye |
|
Bengül Özdemir Sarıkaya
Türkiye |
Dr. Öğr. Üyesi Gül Esma AKDOĞAN KARADAĞ
Türkiye |
|
Mehmet Ali Karagöz
Türkiye |
| Özet |
| The aim was to investigate the possible protective effect of extract, which has anti-inflammatory and antioxidant properties, in the testes in an ischemia-reperfusion (IR) injury model by utilizing molecular, biochemical, histopathological, and immunohistochemical methods. A total of 56 male rats were divided in to 7 equal groups. Ischemia was induced by taking the testicles out of the scrotum and rotating them 720° and after 3 h reperfusion was induced. extract was administered 3 h before ischemia. The reperfusion groups were treated by oral gavage 1 h before reperfusion. Following the 3-h reperfusion period, tissue and blood samples were collected. Histopathologically, H&E staining showed disruption in the seminiferous tubule structure in the ischemia and IR groups SOD levels decreased significantly in the IR group compared to the control group, whereas Berberis vulgaris did not change SOD levels following IR at 300 and 600 mg/kg doses. At the dose of 600 mg/kg, significantly increased SOD levels compared to the ischemia group CAT activity was significantly higher in the BV300 and BV600 groups compared to the ischemia group. CAT activity was significantly lower in the IR group compared to the ischemia group (p < 0.001). When compared to the control group, the ischemia group had a roughly 3-fold increase in caspase-3 expression. In the IR group, this ratio was dramatically increased-roughly 5-fold. However, the antiapoptotic gene Bcl-2 expression was significantly decreased in both the ischemia and IR groups compared to the control group. |
| Anahtar Kelimeler |
| Berberis vulgaris | caspase-3 | bcl-2 | ischemia and reperfusion | testes |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Frontiers in pharmacology |
| Dergi ISSN | 1663-9812 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2025 |
| Cilt No | 16 |
| Sayı | 1514676 |
| Sayfalar | 1 / 10 |
| Doi Numarası | 10.3389/fphar.2025.1514676 |
| Makale Linki | https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1514676/full |
| Atıf Sayıları |
