Design, synthesis, and biological studies of isoniazid-based hydrazone Derivatives: Antibacterial, anticancer, and enzyme inhibitory properties
Yazarlar (7)
Doç. Dr. Erbay KALAY Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Işıl Nihan Korkmaz Muş Alparslan Üniversitesi, Türkiye
Fatma Necmiye Kacı
St James's University Hospital, Türkiye
St James's University Hospital, Türkiye
Dr. Öğr. Üyesi Osman Nuri Aslan Atatürk Üniversitesi, Türkiye
Doç. Dr. Pınar Güller Atatürk Üniversitesi, Türkiye
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
Doç. Dr. Ramazan Kalın Erzurum Technical University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Archives of Biochemistry and Biophysics (Q2) | ||
| Dergi ISSN | 0003-9861 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2025 |
| Cilt / Sayı / Sayfa | 770 / 1 / 110450–0 | DOI | 10.1016/j.abb.2025.110450 |
| Makale Linki | https://doi.org/10.1016/j.abb.2025.110450 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Discovery of novel and effective molecules is of vital importance in solving global health problems such as cancer, neurodegenerative diseases and antibiotic resistance. In this study, a series of isoniazid-based hydrazone derivatives were synthesized for the first time via the condensation of isoniazid with structurally diverse aldehydes, including Mannich base, acylated, and sulfonate-containing derivatives. The primary focus was to assess their anticancer properties, antibacterial efficacy, and enzyme inhibition potential, contributing to the development of promising therapeutic agents. In addition, enzyme inhibition mechanisms were predicted by molecular docking methods, structural explanations were made for the biological activities and drug likeness characters of these molecules. The highest inhibitory effects were exhibited by compounds 6a for hCAI, 5b for hCAII, and 6a for AChE with Ki constants of 0.020 ± 0 … |
| Anahtar Kelimeler |
| Antibacterial activity | Anticancer activity | Enzyme inhibition | Hydrazones | Molecular docking |
Science Direct
Design, synthesis, and biological studies of isoniazid-based hydrazone Derivatives: Antibacterial, anticancer, and enzyme inhibitory properties
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 14 |
| Scopus | 13 |
| Google Scholar | 17 |