Design, synthesis, and aldose reductase inhibition assessment of novel Quinazolin-4(3H)-one derivatives with 4-Bromo-2-Fluorobenzene functionality
Yazarlar (5)
Pelin Tokalı
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Prof. Dr. Yeliz Demir Ardahan Üniversitesi, Türkiye
Arş. Gör. Furkan Çakır Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Doç. Dr. Halil Şenol Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Bioorganic Chemistry (Q1) | ||
| Dergi ISSN | 0045-2068 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2025 |
| Cilt / Sayı / Sayfa | 162 / 1 / 108614–0 | DOI | 10.1016/j.bioorg.2025.108614 |
| Makale Linki | https://doi.org/10.1016/j.bioorg.2025.108614 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Aldose reductase (ALR2) inhibition is a promising therapeutic strategy for managing diabetes-related complications, including neuropathy, retinopathy, and nephropathy. This study reports the design, synthesis, and biological evaluation of eighteen novel quinazolin-4(3H)-one derivatives incorporating a 4-bromo-2-fluorobenzylidene moiety as ALR2 inhibitors. Among the synthesized compounds, the cyclohexyl-substituted derivative (compound 9) exhibited the highest potency as a competitive ALR2 inhibitor, with a Ki of 0.064 μM—15 times more effective than the standard inhibitor epalrestat (EPR) (Ki = 0.967 μM). Molecular docking and dynamics simulations revealed stable binding interactions between compound 9 and key residues in the ALR2 active site, such as Trp-111, Tyr-209, Trp-20, and Ser-302. Cytotoxicity assays on HUVEC and BEAS-B2 cell lines demonstrated that the most active compounds, were … |
| Anahtar Kelimeler |
| Aldose reductase | Inhibition | Molecular docking | Molecular dynamics | Quinazolin-4(3H)-one |
Science Direct
Design, synthesis, and aldose reductase inhibition assessment of novel Quinazolin-4(3H)-one derivatives with 4-Bromo-2-Fluorobenzene functionality
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 33 |
| Scopus | 32 |
| Google Scholar | 36 |