New Potential Agent in Ovarian Ischemia Reperfusion Injury: Alpha Pinene

GÜLAKAR, BAŞAK; Şebin, Saime Özbek; Laloğlu, Esra; Tanyeli, Ayhan; Güler, Mustafa Can; CAN, SERPİL

doi:10.1002/jbt.70318

New Potential Agent in Ovarian Ischemia Reperfusion Injury: Alpha Pinene

Yazarlar (6)

Arş. Gör. Başak GÜLAKAR Kafkas Üniversitesi, Türkiye

Saime Özbek Şebin Türkiye

Esra Laloğlu Türkiye

Ayhan Tanyeli Türkiye

Mustafa Can Güler Türkiye

Prof. Dr. Serpil CAN Kafkas Üniversitesi, Türkiye

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	Journal of Biochemical and Molecular Toxicology (Q2)
Dergi ISSN	1095-6670 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	SCI-Expanded
Makale Dili	Türkçe	Basım Tarihi	05-2025
Cilt / Sayı / Sayfa	39 / 6 / 1–9	DOI	10.1002/jbt.70318
Makale Linki	https://doi.org/10.1002/jbt.70318

Özet

ABSTRACT
Ovarian torsion causes problems such as infertility in women due to ischemia‐reperfusion (I/R) injury. α‐Pinene (AP) is a monoterpene with known anti‐inflammatory, antioxidant, and antiapoptotic impacts. In the present investigation, the protective impact of AP was examined in the ovarian I/R model. 28 Wistar‐Albino female rats were used in the study. TNF‐α, IL‐1β, IL‐10, MDA, IMA, SOD, and SIRT‐1 levels were determined in ovarian tissue by ELISA method. Histopathological and immunohistochemical analyses were conducted to determine Bcl‐2, Caspase‐3, LC3B, and NFκB levels in ovarian tissues. TNF‐α, IL‐1β, IMA, and MDA levels were reduced in the treatment groups than the I/R group dose‐dependent, while IL‐10, SOD, and SIRT‐1 levels increased substantially. Caspase‐3 immunoreactivity declined in the treatment groups while Bcl‐2 levels increased. LC3B and NFκB levels, which rise with I/R injury, were reduced considerably in the treatment groups. In addition, hemorrhage, edema, vascular congestion, and follicular degeneration due to I/R injury decreased in the treatment groups. The present investigation shows that AP has anti‐inflammatory, antiapoptotic, and autophagy inhibitory effects against I/R damage in ovarian tissues and reduces oxidative stress. The results indicate that AP may be a potential protective agent in clinical use. Further research is needed before AP can be used in the clinic.

Anahtar Kelimeler

inflammation | ovarian ischemia-reperfusion injury | oxidative stress | alpha-Pinene

BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları
Web of Science	5

New Potential Agent in Ovarian Ischemia Reperfusion Injury: Alpha Pinene

Dergi Adı	JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
Yayıncı	John Wiley & Sons Inc.
Açık Erişim	Hayır
ISSN	1095-6670
E-ISSN	1099-0461
CiteScore	6,0
SJR	0,772
SNIP	0,725

New Potential Agent in Ovarian Ischemia Reperfusion Injury: Alpha Pinene

Paylaş