New Potential Agent in Ovarian Ischemia Reperfusion Injury: Alpha Pinene
 
Yazarlar (6)
Arş. Gör. Başak GÜLAKAR Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Saime Özbek Şebin Türkiye
Doç. Dr. Esra Laloğlu Türkiye
Prof. Dr. Ayhan Tanyeli Türkiye
Doç. Dr. Mustafa Can Güler Türkiye
Prof. Dr. Serpil CAN Kafkas Üniversitesi, Türkiye
Makale Türü Açık Erişim Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (Q2)
Dergi ISSN 1095-6670 Dergi Bilgileri (2025)
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili Türkçe Basım Tarihi 05-2025
Cilt / Sayı / Sayfa 39 / 6 / 1–9 DOI 10.1002/jbt.70318
Makale Linki https://doi.org/10.1002/jbt.70318
UAK Araştırma Alanları
Fizyoloji
Özet
ABSTRACT
Ovarian torsion causes problems such as infertility in women due to ischemia‐reperfusion (I/R) injury. α‐Pinene (AP) is a monoterpene with known anti‐inflammatory, antioxidant, and antiapoptotic impacts. In the present investigation, the protective impact of AP was examined in the ovarian I/R model. 28 Wistar‐Albino female rats were used in the study. TNF‐α, IL‐1β, IL‐10, MDA, IMA, SOD, and SIRT‐1 levels were determined in ovarian tissue by ELISA method. Histopathological and immunohistochemical analyses were conducted to determine Bcl‐2, Caspase‐3, LC3B, and NFκB levels in ovarian tissues. TNF‐α, IL‐1β, IMA, and MDA levels were reduced in the treatment groups than the I/R group dose‐dependent, while IL‐10, SOD, and SIRT‐1 levels increased substantially. Caspase‐3 immunoreactivity declined in the treatment groups while Bcl‐2 levels increased. LC3B and NFκB levels, which rise with I/R injury, were reduced considerably in the treatment groups. In addition, hemorrhage, edema, vascular congestion, and follicular degeneration due to I/R injury decreased in the treatment groups. The present investigation shows that AP has anti‐inflammatory, antiapoptotic, and autophagy inhibitory effects against I/R damage in ovarian tissues and reduces oxidative stress. The results indicate that AP may be a potential protective agent in clinical use. Further research is needed before AP can be used in the clinic.
Anahtar Kelimeler
inflammation | ovarian ischemia-reperfusion injury | oxidative stress | alpha-Pinene
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Web of Science 10
New Potential Agent in Ovarian Ischemia Reperfusion Injury: Alpha Pinene

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İletişim
  • Kafkas Üniversitesi Rektörlüğü (36100) Merkez / KARS
  • unis@kafkas.edu.tr 4742251150 (474)225-1160
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