| Yazarlar (6) |
Arş. Gör. Ömer Faruk BAŞER
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Mahmut KARAPEHLİVAN
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Abdulsamed KÜKÜRT
Kafkas Üniversitesi, Türkiye |
Arş. Gör. Ayfer YILDIZ UYSAL
Kafkas Üniversitesi, Türkiye |
Esra Kafkas
Kafkas University, Türkiye |
Prof. Dr. Serpil DAĞ
Kafkas Üniversitesi, Türkiye |
| Özet |
| In our study, the potential protective effects of boric acid (BA) against ovarian damage induced by 3-nitropropionic acid (3-NPA) were investigated. In an experiment conducted on female Wistar rats, the animals were divided into groups receiving control, 3-NPA, 3-NPA + BA, and BA only. 3-NPA triggers oxidative stress in the body by inducing excessive production of reactive oxygen species (ROS), leading to cellular damage and apoptosis. Experimental results showed that oxidative stress markers (MDA, GSH, and GSH-Px) increased in the group treated with 3-NPA, along with elevated inflammatory and apoptotic indicators (TNF-α, IL-6, NF-κB, caspase 3, and 9). Moreover, significant histopathological findings such as degeneration, necrosis, and oocyte loss in follicles were observed. Boric acid application significantly reduced these adverse effects, enhancing antioxidant defense and providing protective effects on ovarian tissue. In conclusion, it was observed that BA's antioxidant and anti-apoptotic properties exhibited protective potential against 3-NPA-related ovarian damage, with a positive impact on reproductive health. The study suggests that BA might be used as a supportive agent in diseases of the female reproductive system. |
| Anahtar Kelimeler |
| 3-NPA | Apoptosis | Boric acid | Ovarian | Oxidative stress | Reproduction |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Biological trace element research |
| Dergi ISSN | 1559-0720 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCOPUS |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2025 |
| Doi Numarası | 10.1007/s12011-025-04725-8 |
| Atıf Sayıları |
