Design, synthesis, characterization, in silico studies, and in vitro anticancer evaluation of novel 7-methoxyquinolone-substituted triazole hybrids
Yazarlar (6)
Lemıye Allıto
Kafkas Üniversitesi, Türkiye
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ferah Cömert Önder Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Doç. Dr. Ramazan Demirel Kafkas Üniversitesi, Türkiye
Alper Önder
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Prof. Dr. Özkan ÖZDEN Kafkas Üniversitesi, Türkiye
Doç. Dr. Musa ERDOĞAN Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Future Medicinal Chemistry (Q2) | ||
| Dergi ISSN | 1756-8919 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2025 |
| Cilt / Sayı / Sayfa | 17 / 13 / 1559–1573 | DOI | 10.1080/17568919.2025.2533003 |
| Makale Linki | https://doi.org/10.1080/17568919.2025.2533003 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| AimsThe quinolone scaffold is a crucial member of the heterocyclic compound family in modern medicinal chemistry, exhibiting a broad range of biological activities. Since 4-quinolones are known to interact with significant drug targets, and due to the remarkable pharmacological properties of 1,2,3-triazole compounds, a molecular hybridization approach was used to design novel 7-methoxyquinolone-substituted triazole hybrid conjugates (QN1-QN11).Materials and methodsThese hybrid compounds were evaluated to determine their anticancer activities in various breast and colon cancer cell lines, including BT20, MDA-MB-231, MCF7, and HT29. In addition, the apoptotic-like morphological changes in aggressive MDA-MB-231 cells were observed following treatment with the compounds for 48 hours. In silico studies, including molecular docking, molecular dynamics (MD) simulation, and MM/GBSA calculations … |
| Anahtar Kelimeler |
| anticancer | click chemistry | MD simulation | molecular docking | Quinolone |
| Atıf Sayıları | |
| Scopus | 3 |
| Google Scholar | 3 |