| Yazarlar (6) |
Lemıye Allıto
|
|
Ferah Cömert Önder
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
|
Ramazan Demirel
|
|
Alper Önder
Türkiye |
Prof. Dr. Özkan ÖZDEN
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Musa ERDOĞAN
Kafkas Üniversitesi, Türkiye |
| Özet |
| AimsThe quinolone scaffold is a crucial member of the heterocyclic compound family in modern medicinal chemistry, exhibiting a broad range of biological activities. Since 4-quinolones are known to interact with significant drug targets, and due to the remarkable pharmacological properties of 1,2,3-triazole compounds, a molecular hybridization approach was used to design novel 7-methoxyquinolone-substituted triazole hybrid conjugates (QN1-QN11).Materials and methodsThese hybrid compounds were evaluated to determine their anticancer activities in various breast and colon cancer cell lines, including BT20, MDA-MB-231, MCF7, and HT29. In addition, the apoptotic-like morphological changes in aggressive MDA-MB-231 cells were observed following treatment with the compounds for 48 hours. In silico studies, including molecular docking, molecular dynamics (MD) simulation, and MM/GBSA calculations ... |
| Anahtar Kelimeler |
| anticancer | click chemistry | MD simulation | molecular docking | Quinolone |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Future Medicinal Chemistry |
| Dergi ISSN | 1756-8919 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2025 |
| Cilt No | 17 |
| Sayı | 1 |
| Sayfalar | 1 / 15 |
| Doi Numarası | 10.1080/17568919.2025.2533003 |
| Makale Linki | https://doi.org/10.1080/17568919.2025.2533003 |
