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Lemıye Allıto
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Ferah Comert Onder
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Ramazan Demirel
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Alper Onder
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Özkan Özden
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Musa Erdoğan
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| Özet |
| AimsThe quinolone scaffold is a crucial member of the heterocyclic compound family in modern medicinal chemistry, exhibiting a broad range of biological activities. Since 4-quinolones are known to interact with significant drug targets, and due to the remarkable pharmacological properties of 1,2,3-triazole compounds, a molecular hybridization approach was used to design novel 7-methoxyquinolone-substituted triazole hybrid conjugates (QN1-QN11).Materials and methodsThese hybrid compounds were evaluated to determine their anticancer activities in various breast and colon cancer cell lines, including BT20, MDA-MB-231, MCF7, and HT29. In addition, the apoptotic-like morphological changes in aggressive MDA-MB-231 cells were observed following treatment with the compounds for 48 hours. In silico studies, including molecular docking, molecular dynamics (MD) simulation, and MM/GBSA calculations ... |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Future Medicinal Chemistry |
| Dergi ISSN | 1756-8919 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI Exp |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2025 |
| Sayfalar | 1 / 15 |
| Doi Numarası | 10.1080/17568919.2025.2533003 |
| Makale Linki | https://doi.org/10.1080/17568919.2025.2533003 |
