In vivo and in silico evaluation of the toxicological and biochemical effects of Cd 4-formylbenzoate pyrazine complex on Galleria mellonella L. (Lepidoptera: Pyralidae)
Yazarlar (7)
Dr. Öğr. Üyesi Ahmet HARMANKAYA Kafkas Üniversitesi, Türkiye
Doç. Dr. Serkan Sugeçti Zonguldak Bülent Ecevit Üniversitesi, Türkiye
Doç. Dr. Mustafa SERTÇELİK Kafkas Üniversitesi, Türkiye
Öğr. Gör. Cihat Çelik Zonguldak Bulent Ecevit University, Türkiye
Prof. Dr. Ender Büyükgüzel Zonguldak Bulent Ecevit University, Türkiye
Prof. Dr. Hacali NECEFOĞLU Kafkas Üniversitesi, Türkiye
Prof. Dr. Kemal Büyükgüzel Zonguldak Bulent Ecevit University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Asia Pacific Entomology (Q2) | ||
| Dergi ISSN | 1226-8615 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2025 |
| Cilt / Sayı / Sayfa | 28 / 3 / 1–7 | DOI | 10.1016/j.aspen.2025.102443 |
| Makale Linki | https://doi.org/10.1016/j.aspen.2025.102443 | ||
| UAK Araştırma Alanları |
Anorganik Kimya
Biyokimya
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| Özet |
| Environmental pollution resulting from the use of insecticides in conventional pest control necessitates the exploration of novel chemical compounds with reduced toxicity. In this study, the Cd 4-formylbenzoate pyrazine complex was initially investigated in silico to assess its interaction with the juvenile hormone of Galleria mellonella. The binding affinity of the complex to the juvenile hormone was determined to be −8.1 kcal/mol. Based on the strong binding affinity observed in the in silico analysis, the biochemical effects of the complex on G. mellonella hemolymph were further evaluated in vivo. The results demonstrated a significant increase in the levels of alanine transaminase, aspartate transaminase, and gamma-glutamyl transferase, which are key enzymes involved in amino acid metabolism in the exposed samples. Furthermore, cellular damage was observed in the hemolymph following exposure to the … |
| Anahtar Kelimeler |
| Galleria mellonella | Metal complex | Pest control | Transferase enzyme |
Science Direct
In vivo and in silico evaluation of the toxicological and biochemical effects of Cd 4-formylbenzoate pyrazine complex on Galleria mellonella L. (Lepidoptera: Pyralidae)
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |