| Yazarlar (7) |
Dr. Öğr. Üyesi Ahmet HARMANKAYA
Kafkas Üniversitesi, Türkiye |
Serkan Sugeçti
Bülent Ecevit University, Turkey |
Doç. Dr. Mustafa SERTÇELİK
Kafkas Üniversitesi, Türkiye |
|
Cihat Çelik
Bülent Ecevit University, Turkey |
|
Ender Büyükgüzel
Bülent Ecevit University, Turkey |
Prof. Dr. Hacali NECEFOĞLU
Kafkas Üniversitesi, Türkiye |
|
Kemal Büyükgüzel
Bülent Ecevit University, Turkey |
| Özet |
| Environmental pollution resulting from the use of insecticides in conventional pest control necessitates the exploration of novel chemical compounds with reduced toxicity. In this study, the Cd 4-formylbenzoate pyrazine complex was initially investigated in silico to assess its interaction with the juvenile hormone of Galleria mellonella. The binding affinity of the complex to the juvenile hormone was determined to be −8.1 kcal/mol. Based on the strong binding affinity observed in the in silico analysis, the biochemical effects of the complex on G. mellonella hemolymph were further evaluated in vivo. The results demonstrated a significant increase in the levels of alanine transaminase, aspartate transaminase, and gamma-glutamyl transferase, which are key enzymes involved in amino acid metabolism in the exposed samples. Furthermore, cellular damage was observed in the hemolymph following exposure to the complex. Additionally, crucial metabolic enzymes, including lactate dehydrogenase, creatine kinase, alkaline phosphatase, and amylase, were adversely affected. Collectively, these findings indicate that the Cd 4-formylbenzoate pyrazine complex exerts toxic effects on the model pest G. mellonella. |
| Anahtar Kelimeler |
| Galleria mellonella | Metal complex | Pest control | Transferase enzyme |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Asia Pacific Entomology |
| Dergi ISSN | 1226-8615 Wos Dergi Scopus Dergi |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2025 |
| Cilt No | 28 |
| Sayı | 3 |
| Doi Numarası | 10.1016/j.aspen.2025.102443 |
| Atıf Sayıları |
