New Quinazolin-4(3H)-One–Thiazolidine-2,4-Dione Hybrids as Dual Inhibitors of α-Glycosidase and Aldose Reductase: The Synthetic, In Vitro, and In Silico Approaches
Yazarlar (5)
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
Prof. Dr. Yeliz Demir Ardahan Üniversitesi, Türkiye
Pelin Tokalı
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Arş. Gör. Şeyma Ateşoğlu Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Doç. Dr. Halil Şenol Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Biochemical and Molecular Toxicology (Q2) | ||
| Dergi ISSN | 1095-6670 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2025 |
| Cilt / Sayı / Sayfa | 39 / 8 / – | DOI | 10.1002/jbt.70412 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/10.1002/jbt.70412 | ||
| UAK Araştırma Alanları |
Organik Kimya
|
||
| Özet |
| The impact of diabetes and its complications on individuals is profound, leading to severe health issues and reduced quality of life. This study aimed the design, synthesis, and evaluation of new quinazolin‐4(3H)‐one‐thiazolidine‐2,4‐dione hybrids as dual inhibitors targeting α‐glycosidase (α‐Gly) and aldose reductase (ALR2), two key enzymes implicated in type 2 diabetes mellitus (T2DM) and its complications. Thirteen compounds were synthesized and characterized using FTIR, NMR, and HRMS. In vitro assays revealed potent inhibition of α‐Gly and ALR2, with compound 9 (phenethyl substituted) emerging as the most potent inhibitor for both enzymes (α‐Gly Ki = 0.355 µM, ALR2 Ki = 0.106 µM). Molecular docking and dynamics simulations confirmed the stable binding of compound 9 in the active sites of both enzymes, with key interactions such as hydrogen bonds and π–π stacking contributing to its … |
| Anahtar Kelimeler |
| ADME-T | aldose reductase | diabetes mellitus | molecular docking | Quinazolin-4(3H)-one | thiazolidine-2,4-dione | α-glycosidase |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 33 |
| Scopus | 31 |
| Google Scholar | 34 |