| Yazarlar (6) |
Özlem GÜRSOY KOL
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Sevda MANAP
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Murat BEYTUR
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Fevzi AYTEMİZ
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Muzaffer ALKAN
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Haydar YÜKSEK
Kafkas Üniversitesi, Türkiye |
| Özet |
| In the present study, 3-alkyl/aryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) reacted with 3-ethoxy-4-(3-methoxybenzoxy)-benzaldehyde (2) to obtain the corresponding nine new 2-ethoxy-4-[(3-alkyl/aryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)azomethine]-phenyl 3-methoxybenzoates (3). The compounds 3 were also treated with 4-piperidinecarboxamide in the presence of formaldehyde according to the Mannich reaction to synthesize 2-ethoxy-4-{[3-alkyl/aryl-1-(4-piperidinecarboxamide-1-yl-methyl)-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl]-azomethine}-phenyl 3-methoxy-benzoates (4). The structures of Schiff base and Mannich base derivatives were identified with spectral methods. Antimicrobial and antioxidant screening were carried out and discussed. Mannich base derivatives were found to be more active than Schiff bases in the biological screening. The effect values of Mannich Base derivatives dominate Neomycin and Streptomycin antibiotics. |
| Anahtar Kelimeler |
| 1,2,4-triazole-5-one | antimicrobial activity | antioxidant activity | Mannich base | Schiff base |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Research in Pharmacy |
| Dergi ISSN | 2630-6344 Wos Dergi Scopus Dergi |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2025 |
| Cilt No | 29 |
| Sayı | 2 |
| Sayfalar | 692 / 704 |
| Doi Numarası | 10.12991/jrespharm.1664907 |
| Atıf Sayıları |
