Next-generation sequencing of CCR5, CXCR4, and IFNAR1 variants in relation to HIV-1 disease progression and ART response
Yazarlar (7)
Kubra Cigdem Pekkoc-Uyanik
Haliç Üniversitesi, Türkiye
Haliç Üniversitesi, Türkiye
Zeynep Gizem Todurga-Seven
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty Of Medicine, Türkiye
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty Of Medicine, Türkiye
Andleeb Shahzadi
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty Of Medicine, Türkiye
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty Of Medicine, Türkiye
Haktan Sonmez
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty Of Medicine, Türkiye
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty Of Medicine, Türkiye
Dr. Öğr. Üyesi Sevcan MERCAN Kafkas Üniversitesi, Türkiye
Prof. Dr. Bilgul Mete İstanbul University-Cerrahpaşa Cerrahpaşa Faculty Of Medicine, Türkiye
Fehmi Tabak
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty Of Medicine, Türkiye
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty Of Medicine, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Scientific Reports (Q1) | ||
| Dergi ISSN | 2045-2322 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2025 |
| Cilt / Sayı / Sayfa | 15 / 1 / – | DOI | 10.1038/s41598-025-11843-9 |
| Makale Linki | https://doi.org/10.1038/s41598-025-11843-9 | ||
| Özet |
| HIV, which causes acquired immune deficiency syndrome (AIDS), invades the host cell via the CD4 receptor and CCR5 or CXCR4 co-receptors. Interferons induced early in HIV infection induce an antiviral defense mechanism through IFNAR signaling. Our study aimed to examine the relationship between CCR5, CXCR4, and IFNAR1 gene variations as a risk factor in HIV + patients and their response to their clinical parameters. Targeted next-generation sequencing (tNGS) was used to perform molecular genotyping analysis of the CCR5, CXCR4, and IFNAR1 genes in genomic DNA from 22 HIV + patients and 25 healthy individuals as controls. We detected 13 rare mutations in the study, including 3 missense, 1 synonymous, 2 5′UTR, 4 3′UTR, and 1 frameshift variation. We also analyzed 6 common variants in the IFNAR1 and CXCR4 genes. HIV + patients carrying the homozygous TT genotype of the … |
| Anahtar Kelimeler |
| CCR5 | CXCR4 | Genetic variation | HIV | IFNAR1 | Next-generation sequencing | Polymophism |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 3 |
| Google Scholar | 3 |