Effects of vitamin D and common nettle ( Urtica dioica ) extract administration on Mn-SOD and Catalase (CAT) secretion in the colon tissues of rats with experimentally induced Crohn’s disease
Yazarlar (4)
Doç. Dr. Şükran YEDİEL ARAS Kafkas Üniversitesi, Türkiye
Doç. Dr. Arzu Gezer Atatürk Üniversitesi, Türkiye
Behzad Mokhtare
Türkiye
Türkiye
Prof. Dr. Ebru KARADAĞ SARI Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | BIOTECHNIC & HISTOCHEMISTRY (Q4) | ||
| Dergi ISSN | 1052-0295 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2025 |
| Cilt / Sayı / Sayfa | 100 / 1 / 1–7 | DOI | 10.1080/10520295.2024.2434753 |
| Makale Linki | https://doi.org/10.1080/10520295.2024.2434753 | ||
| UAK Araştırma Alanları |
Veteriner Histoloji ve Embriyolojisi
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| Özet |
| We have examined some effects of administering vitamin D and extract of common nettle () to rats with experimentally induced Crohn's disease (CR). Body weight and colon length were lower in the CR group than in normal controls, whereas scores for histopathologic changes seen in sections stained by the H&E and PAS methods were lower in rats with CR than in those that also received either vitamin D (CRD) or nettle extract (CRI). Strong manganese-superoxide dismutase (Mn-SOD) immunoreactivity was detected in the crypt epithelium of the CR and CRI groups and in the lymphoid tissue of the CRD group. Weak catalase (CAT) immunoreactivity in the crypt epithelium in the CR, CRI, and CRD groups and strong CAT immunoreactivity in the lymphoid tissue in the CR group were also observed. Our results reveal that administering either vitamin D and common nettle extract can have augment Mn-SOD and CAT expression in colon tissues and contribute to alleviation of some complications of experimental Crohn's disease. |
| Anahtar Kelimeler |
| Catalase | common nettle | Crohn's disease | Mn-SOD | treatment | |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |