| Yazarlar (8) |
Arzu Gezer
Atatürk Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Şükran YEDİEL ARAS
Kafkas Üniversitesi, Türkiye |
|
Mustafa Özkaraca
Türkiye |
|
Nurcan Kılıç Baygutalp
Türkiye |
|
Gülhande Gündoğdu
|
Prof. Dr. Ebru KARADAĞ SARI
Kafkas Üniversitesi, Türkiye |
|
Gursel Bedir
|
|
Hilal Üstündağ
Türkiye |
| Özet |
| Monosodium glutamate (MSG), a widely used food additive, has been associated with various health concerns, including potential reproductive toxicity. This study investigated the protective effects of black garlic (BG) ethanol extract against MSG-induced ovarian damage in rats. Thirty-two female rats in estrus were randomly divided into four groups ( = 8 per group): control (saline), BG (250 mg/kg BW), MSG (4 mg/g BW), and BG+MSG (combined treatment). Treatments were administered daily for 14 days. Ovarian tissues were collected for histopathological, immunohistochemical (IHC), and biochemical analyses. Histopathological examination revealed a significant reduction in cystic follicles in the BG+MSG group compared to the MSG group ( < 0.0001). IHC analysis showed decreased immunoreactivity of endothelin-1 and endothelin-2 in the BG+MSG group compared to the MSG group (both < 0.01). Biochemical assays demonstrated significantly increased follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol levels in the BG+MSG group compared to the MSG group (all < 0.05), while progesterone levels were significantly lower in the MSG group compared to the BG+MSG group ( < 0.05). These findings suggest that BG ethanol extract may mitigate MSG-induced ovarian dysfunction in rats by alleviating degenerative changes in follicles and modulating hormonal levels. This study provides insights into potential natural interventions for MSG-related reproductive toxicity. |
| Anahtar Kelimeler |
| black garlic | endothelin-1 | endothelin-2 | follicle | monosodium glutamate | ovary |
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Food Science & Nutrition |
| Dergi ISSN | 2048-7177 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2025 |
| Cilt No | 13 |
| Sayı | 1 |
| Doi Numarası | 10.1002/fsn3.4766 |
| Makale Linki | https://doi.org/10.1002/fsn3.4766 |
| Atıf Sayıları |
