The Effect of Trolox on Oxidative Stress Index and Nitric Oxide Levels
Yazarlar (6)
Dr. Öğr. Üyesi Ahmet HARMANKAYA
Kafkas Üniversitesi, Türkiye
Ayla Özcan
Türkiye
Dr. Öğr. Üyesi Kezban YILDIZ DALGINLI
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Dinçer ERDAĞ
Kafkas Üniversitesi, Türkiye
Yeşim Aydın Dursun
Bingöl Üniversitesi, Türkiye
Büşra Mert
Kafkas Üniversitesi, Türkiye
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Özgün Makale
(Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale)
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| Dergi Adı | Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi | ||
| Dergi ISSN | 2146-0574 | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2021 |
| Cilt / Sayı / Sayfa | 11 / 4 / 3262–3268 | DOI | 10.21597/jist.951122 |
| Makale Linki | https://dergipark.org.tr/en/download/article-file/1819117 | ||
| Özet |
| Free radicals, which are formed as a consequence of endogenic and exogenic factors in cells, that cause oxidative stress in living organisms can be neutralized through catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), A, E, C vitamins, glutathione, ubiquinone, and flavonoids. The aim of this study is to investigate the effect of trolox (6-hydroxy- 2,5,7,8-tetramethylchroman-2-carboxylic acid), a type of vitamin E, on rabbits regarding the total oxidant and antioxidant capacity (TOC, TAC) levels together with the NO levels. In this study, 0.5 ml physiological saline and 1 μmol kg-1 trolox were given respectively to control and experiment rabbits via intraperitoneal (i.p.) route, Plasmas of blood samples, which were obtained in the 1st, 3rd, and 6th hours following injection, were separated and stored at -20 oC until to be analyzed. Plasma TOC, TAC and NO levels were determined spectrophotometrically. When the TOC, TAC, NO levels and OSI values of rabbits that were given trolox were compared to those of the control group, statistically, it was observed that the NO levels were high (p< 0,01) in the 1st, 3rd, and 6th hours; however, there was no alteration in their TAC, TOC levels and OSI values. As a result, it was concluded that trolox given as a single dose to healthy rabbits did not affect TAC TOC levels and OSI value, but the increasing levels of NO might be due to trolox's increasing activity of eNOS. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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