| Yazarlar |
Prof. Dr. Abdullah DOĞAN
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Pınar AKSU KILIÇLE
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Dinçer ERDAĞ
Kafkas Üniversitesi, Türkiye |
Ali Nazmi Can Doğan
Türkiye |
|
Kadir Özcan
Uşak Üniversitesi, Türkiye |
|
Ertan Doğan
Türkiye |
| Özet |
| In this study, the protective effects of cysteamine, putrescine, and the combination of cysteamine and putrescine were investigated in mice with fibrosarcoma induced with 3-methylcholanthrene (3-MC). A total of 135 adult male albino mice (Mus musculus), 2 3 months old and weighing 20 ± 2.0 g, were used in this study. All groups (each consisting of 15 mice) were fed ad libitum. The experimental groups were Group 1 (drinking water), Group 2 (0.2 mL sesame oil s.c.), Group 3 (1 mg 3-MC/0.2 mL sesame oil), Group 4 (0.1% cysteamine), Group 5 (0.1% putrescine), Group 6 (0.1% cysteamine + putrescine), Group 7 (1 mg 3-MC/0.2 sesame oil + 0.1% cysteamine), Group 8 (1 mg 3-MC/0.2 mL sesame oil + 0.1% putrescine), and Group 9 (1 mg 3-MC/0.2 mL sesame oil + 0.1% cysteamine + 0.1% putrescine). Experimental groups were given cysteamine and/or putrescine mixed with drinking water right after being injected with 3-MC subcutaneously. After 7 months, the mice were euthanized by means of cervical dislocation and were evaluated morphologically and histopathologically. The results showed that the number of tumors of 3-MC-induced fibrosarcoma were reduced from the highest to the lowest by cysteamine, cysteamine + putrescine, and putrescine, respectively. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | TURKISH JOURNAL OF VETERINARY AND ANIMAL SCIENCES |
| Dergi ISSN | 1300-0128 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2016 |
| Cilt No | 40 |
| Sayfalar | 575 / 581 |
| Doi Numarası | 10.3906/vet-1510-49 |
| Makale Linki | http://dx.doi.org/10.3906/vet-1510-49 |
| Atıf Sayıları |
