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Akademisyenler > Neşe SANSA > Yayın Detayı

Monoclonal Anti idiotypic Antibody Mimicking the Gastrointestinal Carcinoma Associated Epitope CO17 1A Elicits Antigen Specific Humoral and Cellular Immune Responses in Colorectal Cancer Patients       
Yazarlar (14)
Brigitte Birebent
The Wistar Institute, Amerika Birleşik Devletleri
Edith Mitchell
Thomas Jefferson University, Amerika Birleşik Devletleri
Prof. Dr. Neşe SANSA Prof. Dr. Neşe SANSA
The Wistar Institute, Amerika Birleşik Devletleri
Weiping Li
The Wistar Institute, Amerika Birleşik Devletleri
Rajasekharan Somasundaram
The Wistar Institute, Amerika Birleşik Devletleri
Enkhtsetseg Purev
The Wistar Institute, Amerika Birleşik Devletleri
Diane Hoey
Thomas Jefferson University, Amerika Birleşik Devletleri
Michael Mastrangelo
Thomas Jefferson University, Amerika Birleşik Devletleri
Henry Maguire
Thomas Jefferson University, Amerika Birleşik Devletleri
David T. Harris
Lankenau Hospital, Amerika Birleşik Devletleri
Sridhar Nair
The Wistar Institute, Amerika Birleşik Devletleri
Dewei Cai
The Wistar Institute, Amerika Birleşik Devletleri
Tianqian Zhang
The Wistar Institute, Amerika Birleşik Devletleri
Dorothee M. Herlyn
The Wistar Institute, Amerika Birleşik Devletleri
Devamını Göster
Özet
Monoclonal rat anti-idiotypic antibody (Ab2) BR3E4 mimicking the colorectal carcinoma (CRC)-associated epitope CO17-1A induced antigen-specific humoral and cellular immune responses in mice and rabbits. Ab2 BR3E4 was administered in a phase I trial to CRC patients either as intact IgG or as F(ab′)2 coupled to keyhole limpet hemocyanin (KLH). There was a trend for the F(ab′)2-KLH-immunized patients to show higher immune response rates (18/21 and 5/15 patients with anti-anti-idiotypic antibodies and T cells, respectively) than the IgG-immunized patients (15/23 and 3/15 patients positive). Clinical responses were rare in these patients with liver metastases. © 2002 Elsevier Science Ltd. All rights reserved.
Anahtar Kelimeler
Anti-idiotypic antibody vaccine | Colorectal cancer antigen | Phase-I trial
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı Vaccine
Dergi ISSN 0264-410X Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q4
Makale Dili İngilizce
Basım Tarihi 01-2003
Cilt No 21
Sayı 15
Sayfalar 1601 / 1612
Doi Numarası 10.1016/S0264-410X(02)00752-1
Science Direct
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 9
SCOPUS 9
Google Scholar 21
Monoclonal Anti idiotypic Antibody Mimicking the Gastrointestinal Carcinoma Associated Epitope CO17 1A Elicits Antigen Specific Humoral and Cellular Immune Responses in Colorectal Cancer Patients

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