| Yazarlar (10) |
V Ninichuk
Ludwig-Maximilians-Universität München, Almanya |
|
O Gross
Uniklinik Köln, Almanya |
|
S Segerer
Ludwig-Maximilians-Universität München, Almanya |
|
R Hoffmann
Ludwig-Maximilians-Universität München, Almanya |
|
E Radomska
Ludwig-Maximilians-Universität München, Almanya |
|
A Buchstaller
Ludwig-Maximilians-Universität München, Almanya |
|
R Huss
Ludwig-Maximilians-Universität München, Almanya |
Prof. Dr. Neşe SANSA
Haliç Üniversitesi, Türkiye |
|
D Schlondorff
Ludwig-Maximilians-Universität München, Almanya |
|
Hj Anders
Ludwig-Maximilians-Universität München, Almanya |
| Özet |
| Multipotent mesenchymal stem or stromal cells (MSC) have shown to improve outcome of acute renal injury models, but whether MSC can delay renal failure in chronic kidney disease is not known. We injected primary MSC or saline into mice that lack the α3-chain of type IV collagen (COL4A3), a model of chronic kidney disease with close similarities to human Alport disease. Weekly injections of MSC from week 6 to 10 of life prevented the loss of peritubular capillaries and reduced markers of renal fibrosis, that is, interstitial volume, numbers of smooth muscle actin-positive interstitial cells, and interstitial collagen deposits as compared to saline-injected COL4A3-deficient mice. However, renal function, that is, blood urea nitrogen, creatinine levels, proteinuria as well as survival of COL4A3-deficient mice were not affected by MSC injections. Although MSC were found to localize to kidneys of COL4A3-deficient mice after injection, differentiation into renal cells was not detected. However, MSC expressed growth factors, that is, vascular endothelial growth factor (VEGF) and bone morphogenetic protein-7 under basal culture conditions. In fact, VEGF mRNA levels were increased in kidneys of MSC-injected COL4A3-deficient mice and MSC supernatants enhance endothelial cell proliferation in vitro. Thus, weekly injections with MSC prevent loss of peritubular capillaries possibly owing to local production of growth factors rather than by differentiation into renal cells. The maintenance of interstitial vasculature is associated with less interstitial fibrosis but, is insufficient to delay renal failure and survival of COL4A3-deficient mice. © 2006 International Society of Nephrology. |
| Anahtar Kelimeler |
| Chronic kidney disease | Fibrosis | Kidney | Mesenchymal stem cells | Progression |
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Kidney International |
| Dergi ISSN | 0085-2538 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2006 |
| Cilt No | 70 |
| Sayı | 1 |
| Sayfalar | 121 / 129 |
| Doi Numarası | 10.1038/sj.ki.5001521 |
| Atıf Sayıları | |
| WoS | 222 |
| SCOPUS | 246 |
| Google Scholar | 381 |
