| Yazarlar (11) |
Rahul D. Pawar
Ludwig-Maximilians-Universität München, Almanya |
|
Liliana Castrezana-Lopez
Ludwig-Maximilians-Universität München, Almanya |
|
Ramanjaneyulu Allam
Ludwig-Maximilians-Universität München, Almanya |
|
Onkar P. Kulkarni
Ludwig-Maximilians-Universität München, Almanya |
|
Stephan Segerer
Ludwig-Maximilians-Universität München, Almanya |
|
Ewa Radomska
Ludwig-Maximilians-Universität München, Almanya |
|
Tobias N. Meyer
Universität Hamburg, Almanya |
|
Catherine Meyer Schwesinger
Universität Hamburg, Almanya |
Prof. Dr. Neşe SANSA
Bursa Uludağ Üniversitesi, Türkiye |
|
Hermann Josef Gröne
German Cancer Research Center, Almanya |
|
Hans Joachim Anders
Klinikum Der Universität München, Almanya |
| Özet |
| What are the molecular mechanisms of bacterial infections triggering or modulating lupus nephritis? In nephritic MRLlpr/lpr mice, transient exposure to bacterial cell wall components such as lipopeptide or lipopolysaccharide (LPS) increased splenomegaly, the production of DNA autoantibodies, and serum interleukin (IL)-6, IL-12 and tumour necrosis factor (TNF) levels, and aggravated lupus nephritis. Remarkably, bacterial lipopeptide induced massive albuminuria in nephritic but not in non-nephritic mice. This was associated with down-regulation of renal nephrin mRNA and redistribution from its normal localization at foot processes to the perinuclear podocyte area in nephritic MRLlpr/lpr mice. Bacterial lipopeptide activates Toll-like receptor 2 (TLR2), which we found to be expressed on cultured podocytes and glomerular endothelial cells. TNF and interferon (IFN)-β induced TLR2 mRNA and receptor expression in both cell types. Albumin permeability was significantly increased in cultured podocytes and glomerular endothelial cells upon stimulation by bacterial lipopeptide. LPS also induced moderate albuminuria. In summary, bacterial lipopeptide and LPS can aggravate glomerulonephritis but only lipopeptide potently induces severe albuminuria in MRLlpr/lpr mice. © 2008 Blackwell Publishing Ltd. |
| Anahtar Kelimeler |
| Albuminuria | Autoimmunity | Endothelial cells | Podocytes | Toll-like receptors |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Immunology |
| Dergi ISSN | 0019-2805 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2009 |
| Cilt No | 128 |
| Sayı | 1 |
| Doi Numarası | 10.1111/j.1365-2567.2008.02948.x |
| Atıf Sayıları | |
| WoS | 64 |
| SCOPUS | 71 |
| Google Scholar | 82 |
