Nicotinamide complexes of metal(II) furan-2-carboxylates: synthesis, determination of crystal structures, Hirshfeld surface analysis, and in vitro and in silico evaluation of inhibitory properties on CA I, CA II, AChE, BChE, and GR enzymes
Yazarlar (5)
Merve Nar
Gümüşhane Üniversitesi, Türkiye
Gümüşhane Üniversitesi, Türkiye
Murat Şentürk Aǧrı İbrahim Çeçen Üniversitesi, Türkiye
Prof. Dr. Afşin Ahmet Kaya Ondokuz Mayis Üniversitesi, Türkiye
Prof. Dr. Elif Çelenk Kaya Ondokuz Mayıs Üniversitesi, Türkiye
Prof. Dr. Ertan Şahin Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Structural Chemistry (Q3) | ||
| Dergi ISSN | 1040-0400 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2026 |
| Cilt / Sayı / Sayfa | 0 / 1 / 1–20 | DOI | 10.1007/s11224-025-02625-0 |
| Makale Linki | https://doi.org/10.1007/s11224-025-02625-0 | ||
| UAK Araştırma Alanları |
Anorganik Kimya
Spektroskopi
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| Özet |
| In this study, nicotinamide complexes of Cu2⁺, Co2⁺, and Zn2⁺ furan-2-carboxylates were synthesized, and the crystal structures of the complexes were characterized by single crystal X-ray diffraction. The chemical composition and functional groups of the complexes were confirmed using elemental analysis, Fourier transform infrared spectroscopy (FT-IR), ultraviolet–visible region (UV–Vis) spectroscopy, and mass spectrometry (MS). Hirshfeld surface analysis detailed the intermolecular interactions present in the crystal structures of the complexes. The complexes feature a central six-coordinate ion (Cu2⁺, Co2⁺, or Zn2⁺) located on an inversion center, which is bonded to two N atoms from nicotinamide and four O atoms from water molecules. There is a furan 2-carboxylate anion that is not coordinated with metal atoms but links to complex structures via hydrogen bonds. Within the scope of biochemical studies … |
| Anahtar Kelimeler |
| Enzyme inhibitors | Furan-2-carboxylate | Molecular docking | Nicotinamide | X-ray crystallography |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 3 |