| Yazarlar (6) |
Öğr. Gör. Hanife ARDAHANLI
Kafkas Üniversitesi, Türkiye |
Yavuz Derin
Türkiye |
|
Raşit Fikret Yılmaz
Türkiye |
|
Haşim Gül
|
Doç. Dr. Mustafa SERTÇELİK
Kafkas Üniversitesi, Türkiye |
|
Ahmet Tutar
Türkiye |
| Özet |
| AimsTo design, synthesize, and characterize N-(4-bromophenyl)-2-(substituted fluorobenzylidene)hydrazine-1-carbothioamides (II–IV) and evaluate their in vitro cytotoxicity against DLD-1 and MDA-MB-231 cells, supported by molecular docking.Materials & methodsCompounds were obtained by condensations of substituted fluorobenzaldehydes with N-(4-bromophenyl)hydrazinecarbothioamide and characterized by NMR, FTIR, and MS. DLD-1 and MDA-MB-231 cells were exposed to 50–1600 µg/mL for 24 h; viability was measured using a commercial colorimetric assay. Statistics used one-way ANOVA with post hoc tests. Blind docking was performed with CB-Dock2 and interactions inspected in Discovery Studio.ResultsAll compounds decreased viability in a concentration-dependent manner. In MDA-MB-231, Compounds I, II, and IV showed significant effects (ANOVA p < 0.001). In DLD-1, Compound IV … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Future Medicinal Chemistry |
| Dergi ISSN | 1756-8919 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | Türkçe |
| Basım Tarihi | 10-2025 |
| Doi Numarası | 10.1080/17568919.2025.2570969 |
| Makale Linki | https://doi.org/10.1080/17568919.2025.2570969 |
| Atıf Sayıları |
