| Yazarlar (5) |
Murat Kayabaş
Türkiye |
Doç. Dr. Mustafa MAKAV
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Serdar YİĞİT
Kafkas Üniversitesi, Türkiye |
|
Levent Aras
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Levent ŞAHİN
Kafkas Üniversitesi, Türkiye |
| Özet |
| Objective: This study aims to investigate the effect of agomelatine on ischemic injury in an experimentally created head trauma model in rats. Materials and Methods: Groups: 1) control (C) incisions were made to the coronal and lambdoid sutures and a steel disc was placed without creating a controlled impact acceleration model; 2) head trauma (HT) did not receive any treatment after head trauma with a controlled impact acceleration model; 3) agomelatine (A) 20 mg/kg oral agomelatine given for 7 days after incisions were made to the coronal and lambdoid sutures and a steel disc was placed without creating a controlled impact acceleration model; 4) head trauma+agomelatine (HT-A) 20 mg/kg oral agomelatine given for 7 d after head trauma with a controlled impact acceleration model. The rats were humanely euthanized after the study by ethical protocols, and blood and tissue samples were taken. Biochemical (tumor necrosis factor [TNF]-α and interleukin [IL]-6) and histopathological analyses (terminal deoxynucleotidyl transferase dUTP nick end labeling [TUNEL]) were conducted from these samples. Results: A significant difference was found in TNF-α between the HT and HT-A groups (p<0.05). There was a statistically significant increase in IL-6 in the HT group compared to that in the HT-A group (p<0.01). In the histopathological analyses, a decrease in TUNEL-positive cells was observed in the HT-A group compared to that in the HT group Conclusion: As a result, a decrease in both apoptotic cells and inflammatory responses was observed in the HT-A group. Therefore, more studies should be included. |
| Anahtar Kelimeler |
| TNF-α | Rat | IL-6 | Agomelatine | Head Trauma |
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale |
| Dergi Adı | Turkish Journal of Veterinary Research (Online) |
| Dergi ISSN | 2602-3695 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2025 |
| Cilt No | 9 |
| Sayı | 1 |
| Sayfalar | 41 / 47 |
| Doi Numarası | 10.47748/tjvr.1577903 |
| Makale Linki | https://dergipark.org.tr/en/download/article-file/4333672 |
| Atıf Sayıları |
