| Yazarlar (6) |
Doç. Dr. Ümit YILDIRIM
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Mehmet USLU
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Mehmet EZER
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi İsmet Bilger ERİHAN
Kafkas Üniversitesi, Türkiye |
Ali Alper Kahraman
|
Prof. Dr. Seyit Ali BİNGÖL
Kafkas Üniversitesi, Türkiye |
| Özet |
| Objective The purpose of this study is to examine how acute ischemia-reperfusion injury (IRI) in a rat model is affected by replacing human serum albumin (HSA).Material and Methods Thirty-six male Wistar albino rats were randomly divided into six groups: Control, Ischemia, Ischemia-Reperfusion (IR), Placebo, Preoperative Albumin (A1), and Intraoperative Albumin (A2). The renal artery of the kidney was blocked using 3/0 silk sutures to induce ischemia, followed by one hour of reperfusion in certain groups. The A1 group received 20% HSA (2.5 g/kg intraperitoneally) 24 hours before surgery, while the A2 group received the same dose 30 minutes before reperfusion. Samples of kidney and blood tissue were gathered for immunohistochemical, histological, and biochemical assessments. Biochemical parameters included ischemia-modified albumin (IMA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI). Histological assessments measured cortical and medullary damage, while immunohistochemistry evaluated oxidative stress markers such as superoxide dismutase (SOD1), glutathione reductase (GSR), and myeloperoxidase (MPO).Results Biochemical analyses showed no significant differences in TOS, TAS, OSI, and IMA levels between groups. Histological evaluation revealed that the A2 group had reduced kidney damage, particularly in the medulla, compared to the ischemia and placebo groups. Immunohistochemical findings indicated minor differences in oxidative stress marker expression, though not statistically significant.Conclusion Intraoperative HSA replacement has the potential to reduce … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale |
| Dergi Adı | The New Journal of Urology |
| Dergi ISSN | 3023-6940 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2025 |
| Cilt No | 20 |
| Sayı | 3 |
| Sayfalar | 130 / 138 |
| Doi Numarası | 10.33719/nju1631647 |
| Makale Linki | https://doi.org/10.33719/nju1631647 |
| Atıf Sayıları |
