| Yazarlar (10) |
İsmail Bolat
Atatürk Üniversitesi, Türkiye |
Prof. Dr. Enver BEYTUT
Kafkas Üniversitesi, Türkiye |
|
Yavuz Selim Sağlam
Atatürk Üniversitesi, Türkiye |
Doç. Dr. Emin KARAKURT
Kafkas Üniversitesi, Türkiye |
|
Selim Çomaklı
Atatürk Üniversitesi, Türkiye |
|
Betül Orhan
Atatürk Üniversitesi, Türkiye |
|
Muhammet Bahaeddin Dörtbudak
Harran Üniversitesi, Türkiye |
|
Ahmet Melik Acar
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye |
|
Selda Güneş
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye |
|
Murat Çeğindir
Atatürk Üniversitesi, Türkiye |
| Özet |
| BackgroundCanine Transmissible Venereal Tumor (CTVT) is a clonally transmissible, low-grade malignant round-cell tumor that affects dogs of all ages and breeds. Although malignant due to its invasive potential and occasional metastasis, it differs from classical malignancies by its unique ability to undergo spontaneous regression, leading some authors to describe it as benign-like. CTVT progresses through progressive (P), stable (S), and regressive (R) phases. The P phase is characterized by rapid tumor proliferation, while the S phase shows arrested growth and unchanged lesions. Despite numerous studies, the molecular mechanisms underlying these transitions remain incompletely understood.AimThis study aimed to evaluate the role of the TLR4/NF-κB/TNF-α signaling pathway in the P and S phases of CTVT.MethodologyTumor samples from 12 CTVT-positive dogs were classified into P and S phases (n … |
| Anahtar Kelimeler |
| Apoptosis | Canine Transmissible Venereal Tumor | Inflammation | Progressive | Stable |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Tissue and Cell |
| Dergi ISSN | 0040-8166 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2025 |
| Cilt No | 98 |
| Sayı | 1 |
| Doi Numarası | 10.1016/j.tice.2025.103193 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0040816625004756 |
| Atıf Sayıları |
