Sulfonyl Hydrazone Derivatives Targeting Glutathione Reductase: A Potential Strategy for Redox Modulation in Cancer
Yazarlar (6)
Doç. Dr. Erbay KALAY Kafkas Üniversitesi, Türkiye
Halide Sedef Karaman
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Osman Nuri Aslan Atatürk Üniversitesi, Türkiye
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
Doç. Dr. Muhammet Karaman Dokuz Eylül Üniversitesi, Türkiye
Doç. Dr. Musa ERDOĞAN Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemical Biology and Drug Design (Q2) | ||
| Dergi ISSN | 1747-0277 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2025 |
| Cilt / Sayı / Sayfa | 106 / 5 / – | DOI | 10.1111/cbdd.70198 |
| Makale Linki | https://doi.org/10.1111/cbdd.70198 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Glutathione reductase (GR) plays a pivotal role in cellular metabolism by maintaining redox balance and sulfhydryl homeostasis through the regeneration of reduced glutathione (GSH). In tumor cells, GR is overexpressed, supporting enhanced antioxidant defenses and neutralizing the detrimental effects of reactive oxygen species. In this study, a series of sulfonyl hydrazone analogs bearing phenolic Mannich base moieties were synthesized and characterized as potential GR inhibitors. The compounds exhibited inhibitory activity with IC50 values ranging from 198.1 to 3013 nM. In silico analyses revealed that 6a binds to the NADP+ binding site of the hGR enzyme and interacts with key residues involved in electron transfer, leading to reduced enzyme activity. Compound 6a, the most potent hGR enzyme inhibitor identified in this study, exhibited cytotoxic effects against MCF‐7, A549, and HeLa cancer cell lines … |
| Anahtar Kelimeler |
| cell viability | enzyme inhibition | glutathione reductase | molecular docking | sulfonyl hydrazone |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |