Antibacterial and antioxidant activities of novel 2-ethoxy-4-[(4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)azomethine]- phenyl 3-methoxybenzoate derivatives
Yazarlar (6)
Özlem Gürsoy Kol
Kafkas Üniversitesi, Türkiye
Doç. Dr. Sevda MANAP
Kafkas Üniversitesi, Türkiye
Doç. Dr. Murat BEYTUR
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Fevzi AYTEMİZ
Kafkas Üniversitesi, Türkiye
Prof. Dr. Muzaffer ALKAN
Kafkas Üniversitesi, Türkiye
Prof. Dr. Haydar YÜKSEK
Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of research in pharmacy (online) | ||
| Dergi ISSN | 2630-6344 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | E-SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2025 |
| Cilt / Sayı / Sayfa | 29 / 2 / 692–704 | DOI | 10.12991/jrespharm.1664907 |
| Makale Linki | https://doi.org/10.12991/jrespharm.1664907 | ||
| Özet |
| In the present study, 3-alkyl/aryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) reacted with 3-ethoxy-4- (3-methoxybenzoxy)-benzaldehyde (2) to obtain the corresponding nine new 2-ethoxy-4-[(3-alkyl/aryl-4,5-dihydro-1H- 1,2,4-triazol-5-one-4-yl)azomethine]-phenyl 3-methoxybenzoates (3). The compounds 3 were also treated with 4- piperidinecarboxamide in the presence of formaldehyde according to the Mannich reaction to synthesize 2-ethoxy-4-{[3- alkyl/aryl-1-(4-piperidinecarboxamide-1-yl-methyl)-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl]-azomethine}-phenyl 3- methoxy-benzoates (4). The structures of Schiff base and Mannich base derivatives were identified with spectral methods. Antimicrobial and antioxidant screening were carried out and discussed. Mannich base derivatives were found to be more active than Schiff bases in the biological screening. The effect values of Mannich Base derivatives dominate Neomycin and Streptomycin antibiotics. |
| Anahtar Kelimeler |
| Schiff base | Mannich base | 1 | 2 | 4-triazole-5-one | antimicrobial activity | antioxidant activity. |
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