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Knowledge and awareness of nonvalvular atrial fibrillation and anticoagulant therapy: Association with medication adherence in a cross-sectional survey      
Yazarlar (15)
Ayşegül Ülgen Kunak
University Of Health Sciences, Türkiye
Mehmet Kaplan
Gaziantep Üniversitesi, Türkiye
Gönül Açıksarı
T.C. Saglik Bakanligi Istanbul Goztepe Egitim ve Arastirma Hastanesi, Türkiye
Kadir Uğur Mert
Eskişehir Osmangazi Üniversitesi, Türkiye
Serhat Çalışkan
Istanbul Bahcelievler State Hospital, Türkiye
Zeki Şimşek
Kartal Kosuyolu Training And Research Hospital, Türkiye
Özcan Başaran
Muğla Sıtkı Koçman Üniversitesi, Türkiye
Ulaankhuu Batgerel
Acibadem International Hospital, Türkiye
Dr. Öğr. Üyesi Muammer KARAKAYALI Dr. Öğr. Üyesi Muammer KARAKAYALI
Kafkas Üniversitesi, Türkiye
Sinan Demirel
Pendik State Hospital, Türkiye
Murat Gök
Trakya University, Faculty Of Medicine, Türkiye
Zeynep Kolak
Dr. Siyami Ersek Thoracic And Cardiovascular Surgery Training And Research Hospital, Türkiye
Gizem Çabuk
Izmir Tepecik Training And Research Hospital, Türkiye
İbrahim Halil Tanboğa
Istanbul Nisantasi University, Türkiye
Can Yücel Karabay
Dr. Siyami Ersek Thoracic And Cardiovascular Surgery Training And Research Hospital, Türkiye
Devamını Göster
Özet
Background: Nonvalvular atrial fibrillation (NVAF) increases the risk of stroke, which can be reduced with oral anticoagulant (OAC) therapy. However, limited patient knowledge about NVAF and its treatment may compromise medication adherence. This study evaluated the association between NVAF knowledge, anticoagulant awareness, and adherence. Methods: This sub-analysis of the TRAFFIC (Turkish Registry of Atrial Fibrillation in Cardiovascular Clinics) study included 1659 NVAF patients. Disease and treatment knowledge were assessed with structured questionnaires (score range: 0–14). Adherence was evaluated using three key behaviors (score range: 0–6). Multivariable ordinal logistic regression identified independent predictors of adherence. Results: The median age was 70 (62–77) years; 48 % were female. Median NVAF knowledge score was 9.0 (7.0–11.0) and anticoagulant knowledge score was 10.0 (7.0–12.0). Overall, 42 % of patients showed high adherence, 20 % medium adherence, and 38 % low adherence. Both NVAF knowledge (r = 0.316, p < 0.001) and anticoagulant knowledge (r = 0.350, p < 0.001) correlated positively with adherence. In multivariable analysis, education level (OR = 1.312, 95 % CI: 1.121–1.535, p = 0.0007), anticoagulant knowledge (OR = 1.564, 95 % CI: 1.295–1.889, p < 0.0001), NVAF knowledge (OR = 1.172, 95 % CI: 0.974–1.410, p = 0.0016), and younger age (OR = 0.804, 95 % CI: 0.700–0.923, p = 0.0006) independently predicted adherence. Conclusions: Greater knowledge of NVAF and anticoagulant therapy is significantly associated with higher adherence. Educational interventions addressing specific knowledge gaps, especially regarding disease mechanisms and treatment importance, may enhance adherence and reduce adverse outcomes in NVAF patients.
Anahtar Kelimeler
Anticoagulants | Atrial fibrillation | Medication adherence | Patient education | Patient knowledge
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı International Journal of Cardiology
Dergi ISSN 0167-5273 Wos Dergi Scopus Dergi
Dergi Grubu Q2
Makale Dili İngilizce
Basım Tarihi 02-2026
Cilt No 444
Sayı 1
Doi Numarası 10.1016/j.ijcard.2025.134020