| Yazarlar (12) |
Dr. Öğr. Üyesi Roshan RIAZ
Kafkas Üniversitesi, Türkiye |
Muhammad Asif
The Islamia University Of Bahawalpur, Pakistan |
|
Gulnaz Afzal
The Islamia University Of Bahawalpur, Pakistan |
|
Urva-Til-Wusqa
The Islamia University Of Bahawalpur, Pakistan |
|
Mubeen Talib
The Islamia University Of Bahawalpur, Pakistan |
|
Moeen Afzal
The Islamia University Of Bahawalpur, Pakistan |
|
Shanzab Noor
Shenzhen University, Çin |
|
Hafiz Muhammad Nouman
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye |
|
Arooj Ali
The Islamia University Of Bahawalpur, Pakistan |
|
Konul Ahmadova
Western Caspian University Baku, Azerbaycan |
|
Rashid Iqbal
Western Caspian University Baku, Azerbaycan |
|
Riaz Hussain
The Islamia University Of Bahawalpur, Pakistan |
| Özet |
| Copper ferrite nanoparticles are widely studied for their biomedical applications; however, their potential toxicity to hematopoietic and dental tissues remains unclear. This study evaluates oxidative stress, antioxidative enzymatic contents, and histopathological alterations in albino rats exposed to copper ferrite nanoparticles. Male Wistar albino rats were divided into four groups: Group A (control, 0.0mg/kg), Group B (2.5mg/kg), Group C (5.0mg/kg), and Group D (7.5mg/kg) received copper ferrite nanoparticles intravenously for 15 days. Oxidative stress was assessed by measuring thiobarbituric acid-reactive substances (TBARS) and reactive oxygen species (ROS). At the same time, antioxidant defense was evaluated in terms of the estimation of superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) contents. The results showed a dose-dependent increase in TBARS and ROS levels, indicating elevated oxidative stress, along with a significant decline in SOD, POD, and CAT contents, suggesting impaired antioxidant defense mechanisms. Histopathological analysis of teeth revealed structural alterations, including enamel erosion, dentin degeneration, and inflammatory changes, particularly at higher doses. The most severe oxidative and histopathological effects were observed in Group D (7.5mg/kg), indicating potential toxicity associated with exposure to copper ferrite nanoparticles. These findings suggest the need for further research on the long-term effects of copper ferrite nanoparticles on erythrocytes, hematopoietic, and dental tissues, to ensure their safe biomedical use. |
| Anahtar Kelimeler |
| Albino Rats | Antioxidative enzymes | Bone marrow | Copper ferrite | Erythrocytes | Oxidative stress |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SCOPUS dergilerinde yayınlanan tam makale |
| Dergi Adı | International Journal of Agriculture and Biosciences |
| Dergi ISSN | 2305-6622 Scopus Dergi |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2025 |
| Cilt No | 14 |
| Sayı | 5 |
| Sayfalar | 1035 / 1041 |
| Doi Numarası | 10.47278/journal.ijab/2025.099 |
| Atıf Sayıları |
