Design, synthesis, characterization, computational analysis, structure-activity relationship, and investigation of the anticancer potential of novel dibromodibenzoazepine-based hybrid structures
Yazarlar (4)
Azza Allıto
Kafkas Üniversitesi, Türkiye
Kafkas Üniversitesi, Türkiye
Alper Önder
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ferah Cömert Önder Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Doç. Dr. Musa ERDOĞAN Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Molecular Diversity (Q2) | ||
| Dergi ISSN | 1381-1991 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 12-2026 |
| Cilt / Sayı / Sayfa | 0 / 1 / – | DOI | 10.1007/s11030-025-11418-w |
| Makale Linki | https://doi.org/10.1007/s11030-025-11418-w | ||
| UAK Araştırma Alanları |
Fen Bilimleri ve Matematik
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| Özet |
| In this study, ten novel dibromodibenzoazepine-substituted triazole hybrid compounds (AZ1–AZ10) were designed via a molecular hybridization approach and synthesized using click chemistry methodology. In the synthesis, the dibromodibenzoazepine derivative (12) was initially synthesized via bromination. Subsequent propargylation yielded the key intermediate, dibromodibenzoazepine-propargyl derivative (13). The Cu (I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of propargyl derivative (13) with various substituted azide derivatives afforded the target hybrid compounds in high yields. The structures of these compounds were characterized using various spectroscopic techniques, including 1 H NMR, 13 C NMR, and MS. Among the synthesized compounds, AZ9 was determined to have the highest cytotoxicity on breast and colon cancer cell lines, including BT20, MCF7, MDA-MB-231, and HT29 … |
| Anahtar Kelimeler |
| Anticancer | Click chemistry | Dibenzoazepine | MD simulation | Triazole |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 1 |
| Google Scholar | 1 |