Harnessing natures building blocks: potent and safe urease inhibition by simple amino acids
Yazarlar (4)
Fulya Bağ
Kafkas Üniversitesi, Türkiye
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Orhan ULUÇAY Kafkas Üniversitesi, Türkiye
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
Doç. Dr. Halil Şenol Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Bioorganic Chemistry (Q1) | ||
| Dergi ISSN | 0045-2068 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2026 |
| Cilt / Sayı / Sayfa | 169 / 1 / 109419–0 | DOI | 10.1016/j.bioorg.2025.109419 |
| Makale Linki | https://doi.org/10.1016/j.bioorg.2025.109419 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Urease is a key metalloenzyme with broad industrial, agricultural, and medical relevance, and it is implicated in the virulence of numerous pathogenic microorganisms. Elevated urease activity supports the persistence of urease-producing microbes and contributes to nitrogen depletion in agricultural soils. Inhibitors of urease that are effective are therefore discovered and their discovery would be a plus. This research is looking at the possibility of amino acids being the safe, biocompatible, and effective urease inhibitors with prospective use in agriculture and medicine. The inhibition potentials of L-Valine, D-Phenylalanine, L-Methionine, L-Tyrosine, L-Arginine, and D-Threonine (Val, Phe, Met, Tyr, Arg, and Thr for short) against jack bean urease were evaluated systematically. The varying side-chain chemistries (aromatic, sulfur, hydroxyl, and ionic) of these compounds that could be involved in urease binding were … |
| Anahtar Kelimeler |
| Amino acids | Jack bean urease | Molecular docking | Thiourea | Urease inhibition |
Science Direct
Harnessing natures building blocks: potent and safe urease inhibition by simple amino acids
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |
| Scopus | 5 |
| Google Scholar | 5 |