3‐Substituted Triazolone–Benzoate Hybrids: Synthesis, Enzyme Inhibition, Anticancer Activity and ADMET Evaluation by Molecular Docking and Dynamics Studies
Yazarlar (9)
Doç. Dr. Murat BEYTUR Kafkas Üniversitesi, Türkiye
Elif Tarmaşır
Kafkas Üniversitesi, Türkiye
Kafkas Üniversitesi, Türkiye
Öğr. Gör. Ercan Oğuz Iğdır Üniversitesi, Türkiye
Doç. Dr. Alpaslan Bayrakdar Iğdır Üniversitesi, Türkiye
Dr. Öğr. Üyesi İlhan Sabancılar Bitlis Eren Üniversitesi, Türkiye
Doç. Dr. Onur AKYILDIRIM Kafkas Üniversitesi, Türkiye
Doç. Dr. Fikret Türkan Iğdır Üniversitesi, Türkiye
Doç. Dr. Abdülmelik Aras Iğdır Üniversitesi, Türkiye
Prof. Dr. Haydar YÜKSEK Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Drug Development Research (Q1) | ||
| Dergi ISSN | 0272-4391 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2026 |
| Cilt / Sayı / Sayfa | 87 / 1 / 1–18 | DOI | 10.1002/ddr.70222 |
| Makale Linki | https://doi.org/10.1002/ddr.70222 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| In this study, eight 3‐substitued ‐4‐amino‐4,5‐dihydro‐1H‐1,2,4‐triazol‐5‐one compounds were synthesized. The reactions of these compounds with 2‐ethoxy‐4‐formylphenyl benzoate, which was synthesized by the reaction of 3‐ethoxy‐4‐hydroxy benzaldehyde with benzoyl chloride by using triethylamine, were investigated. Eight novel 2‐ethoxy‐4‐(((3‐substitued‐5‐oxo‐1,5‐dihydro‐4H‐1,2,4‐triazol‐4‐yl)imino)methyl)phenyl benzoate compounds were obtained in order to identify the new synthesized compounds by spestroscopic methods including IR, 1H‐NMR and 13C‐NMR used. Concentration ranges of 25, 50, 120, 200, and 400 µg/mL were applied to determine the compund's anti‐cancer properties. The human ovarian cancer cell line (OVCAR‐3) compared with human umbilical vein endothelial cells (HUVEC) and significant results were obtained against the OVCAR‐3 cell line. The enzyme inhibitory … |
| Anahtar Kelimeler |
| 1,2,4-triazol | enzyme inhibition | molecular dynamics | OVCAR-3 | Schiff base |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |