Hematological alterations in erythrogram, leukogram, and thrombogram of rats with doxorubicin-induced renal toxicity
Yazarlar (7)
Arş. Gör. Cemre Aydeğer Türkiye
Dr. Öğr. Üyesi Mehmet Akif Ovalı Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Dr. Öğr. Üyesi Hilmi NUHOĞLU Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Tahir GEZER Kafkas Üniversitesi, Türkiye
Doç. Dr. Mustafa MAKAV Kafkas Üniversitesi, Türkiye
Doç. Dr. Hüseyin Avni Eroğlu Türkiye
| Makale Türü |
Özgün Makale
(Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale)
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| Dergi Adı | Journal of Advances in VetBio Science and Techniques | ||
| Dergi ISSN | 2548-1150 | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | Türkçe | Basım Tarihi | 12-2025 |
| Cilt / Sayı / Sayfa | 10 / 3 / 200–204 | DOI | 10.31797/vetbio.1786702 |
| Makale Linki | https://doi.org/10.31797/vetbio.1786702 | ||
| UAK Araştırma Alanları |
Fizyoloji
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| Özet |
| Doxorubicin (DOX) is a widely used antineoplastic agent in cancer treatment; however, it has several drawbacks that can cause harmful effects on various organs, especially the kidneys. Nevertheless, it does not fully reveal the extent of DOX-induced tissue damage. Therefore, it is crucial to clarify the risks associated with DOX-mediated tissue injury. A total of 14 female Wistar Albino rats were divided into two equal groups: Control and Dox. The Dox group received a single dose of 20 mg/kg DOX. Kidney, liver, and blood samples were collected for further analysis. Hematoxylin-Eosin staining and biochemical tests were conducted to assess DOX-induced tissue damage. Our results showed that the Dox group experienced significant glomerular atrophy. Parameters such as RBC, HGB, HCT, and MCHC were also significantly higher compared to the Control group. No significant differences were observed in liver tissues between the groups. Inflammatory markers were also evaluated. NLR and SII scores showed statistically significant differences between the groups. Administration of DOX caused alterations in erythrocyte and leukocyte parameters, with notable changes in renal tissue characterized by glomerular atrophy. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 1 |