Effects of Silver Nanoparticle‐Loaded 18β‐Glycyrrhetinic Acid on P2X7 Receptor and Endoplasmic Reticulum Stress‐Mediated NLRP3 Inflammasome Activation in Testicular Tissue in an Animal Diabetes Model
Yazarlar (6)
Doç. Dr. Volkan GELEN Kafkas Üniversitesi, Türkiye
Doç. Dr. Ali YEŞİLDAĞ Kafkas Üniversitesi, Türkiye
Doç. Dr. Serkan Ali Akarsu Atatürk Üniversitesi, Türkiye
Doç. Dr. Hülya Kara Atatürk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Deniz Tekiner Atatürk Üniversitesi, Türkiye
Prof. Dr. Adem Kara Erzurum Teknik Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Food Science and Nutrition (Q2) | ||
| Dergi ISSN | 2048-7177 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 11-2025 |
| Cilt / Sayı / Sayfa | 13 / 11 / – | DOI | 10.1002/fsn3.70893 |
| Makale Linki | https://doi.org/10.1002/fsn3.70893 | ||
| UAK Araştırma Alanları |
Analitik Kimya
Elektrokimya
Yüzey Kimyası
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| Özet |
| Diabetes, a metabolic disease characterized by high blood sugar, causes damage to many organs in the body. Accordingly, the present study investigates the effects of silver nanoparticle‐loaded 18β‐glycyrrhetinic acid (AgNP+18β‐GA) on P2X7 receptor and ER stress‐mediated NLRP3 inflammasome activation in testicular tissue. 42 Wistar‐Albino rats aged 6 months were used. The rats were divided into the following seven groups: Control, AgNP+18β‐GA100, DM, DM‐18β‐GA100, DM‐AgNP+18β‐GA50, DM‐AgNP+18β‐GA100, and DM‐AgNP. After the experiment, sperm samples obtained from the rats were evaluated. Oxidative stress markers, serum IL‐1β, and TNF‐α levels were determined in the testicular tissue samples taken separately. In addition, Caspase‐1, NLRP3, P2X7, Caspase‐3, NF‐κB, IRE1, ATF6, and CHOP protein expression levels were evaluated using Western blot analysis of … |
| Anahtar Kelimeler |
| 18β-glycyrrhetinic acid | AgNPs | diabetes | ER-stress | NLRP | P2X7 | rat | testis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 3 |
| Google Scholar | 3 |