Multifunctional theranostic glyconanoprobes for synergistic eradication of breast cancer
Yazarlar (6)
Gülşah Yiğit Erdem Fenerbahçe Üniversitesi, Türkiye
Doç. Dr. Beyza Servet Göncü Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Dr. Öğr. Üyesi Sezen Atasoy Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ayfer YILDIZ UYSAL Kafkas Üniversitesi, Türkiye
Prof. Dr. Serpil DAĞ Kafkas Üniversitesi, Türkiye
Prof. Dr. Aydan Dağ Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF MATERIALS CHEMISTRY B (Q2) | ||
| Dergi ISSN | 2050-750X Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 02-2025 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2025 |
| Cilt / Sayı / Sayfa | 13 / 6 / 2150–2166 | DOI | 10.1039/d4tb02550d |
| Makale Linki | https://doi.org/10.1039/d4tb02550d | ||
| UAK Araştırma Alanları |
Veteriner Patolojisi
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| Özet |
| Theranostic agents hold great promise for personalized medicine by combining diagnostic and therapeutic functions. Herein, two novel multifunctional theranostic glyconanoprobes targeting breast cancer were engineered for synergistic dual chemo-gene therapy and triple chemo-gene-photothermal therapy. Upconversion nanoparticles (UCNPs) were prepared and coated with a Dox-loaded glycopeptide polymer (P-Dox) to form UCNP@P-Dox for improving stability. UCNP@MP-Dox equipped for triple therapy was prepared by combining UCNP@P-Dox with magnetic (FeO, M) nanoparticles with photothermal properties. To regulate the expression of the anti-apoptotic Bcl-2 protein, both UCNP@P-Dox and UCNP@MP-Dox were loaded with anti-Bcl-2 siRNA. Impressive photothermal efficiency and good MRI contrast were demonstrated in preliminary evaluations. Moreover, the UCNP@P-Dox/siRNA nanoprobe for dual therapy was shown in preclinical studies to significantly increase anti-tumor efficacy. experiments in tumor-induced mice showed nanoprobe accumulation in tumors and enhanced antitumor efficacy with combinatorial therapy over Dox and siRNA alone. This study demonstrates the tumor-targeting capability of multifunctional theranostic glyconanoprobes, establishing chemo-gene synergy as a potent therapeutic strategy for breast cancer. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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| Web of Science | 4 |
| PubMed | 1 |