Protective Effect of Boric Acid Against 3-NPA-Induced Ovarian Damage

BAŞER, ÖMER FARUK; KARAPEHLİVAN, MAHMUT; KÜKÜRT, ABDULSAMED; YILDIZ UYSAL, AYFER; Kafkas, Esra; DAĞ, SERPİL

doi:10.1007/s12011-025-04725-8

Protective Effect of Boric Acid Against 3-NPA-Induced Ovarian Damage

Yazarlar (6)

Dr. Öğr. Üyesi Ömer Faruk BAŞER Kafkas Üniversitesi, Türkiye

Prof. Dr. Mahmut KARAPEHLİVAN Kafkas Üniversitesi, Türkiye

Dr. Öğr. Üyesi Abdulsamed KÜKÜRT Kafkas Üniversitesi, Türkiye

Dr. Öğr. Üyesi Ayfer YILDIZ UYSAL Kafkas Üniversitesi, Türkiye

Esra Kafkas

Prof. Dr. Serpil DAĞ Kafkas Üniversitesi, Türkiye

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	BIOLOGICAL TRACE ELEMENT RESEARCH (Q2)
Dergi ISSN	0163-4984 Dergi Bilgileri (2026)
Dergi Tarandığı Indeksler	SCI-Expanded
Makale Dili	İngilizce	Basım Tarihi	02-2026
Kabul Tarihi	17-06-2025	Yayınlanma Tarihi	27-06-2025
Cilt / Sayı / Sayfa	204 / 2 / 1008–1021	DOI	10.1007/s12011-025-04725-8
Makale Linki	https://doi.org/10.1007/s12011-025-04725-8
UAK Araştırma Alanları	Tıbbi Biyokimya

Özet

In our study, the potential protective effects of boric acid (BA) against ovarian damage induced by 3-nitropropionic acid (3-NPA) were investigated. In an experiment conducted on female Wistar rats, the animals were divided into groups receiving control, 3-NPA, 3-NPA + BA, and BA only. 3-NPA triggers oxidative stress in the body by inducing excessive production of reactive oxygen species (ROS), leading to cellular damage and apoptosis. Experimental results showed that oxidative stress markers (MDA, GSH, and GSH-Px) increased in the group treated with 3-NPA, along with elevated inflammatory and apoptotic indicators (TNF-α, IL-6, NF-κB, caspase 3, and 9). Moreover, significant histopathological findings such as degeneration, necrosis, and oocyte loss in follicles were observed. Boric acid application significantly reduced these adverse effects, enhancing antioxidant defense and providing protective effects on ovarian tissue. In conclusion, it was observed that BA's antioxidant and anti-apoptotic properties exhibited protective potential against 3-NPA-related ovarian damage, with a positive impact on reproductive health. The study suggests that BA might be used as a supportive agent in diseases of the female reproductive system.

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Atıf Sayıları
Web of Science	6
PubMed	4

Protective Effect of Boric Acid Against 3-NPA-Induced Ovarian Damage

APA

Başer, Ö. F., Karapehlivan, M., Kükürt, A., Uysal, A. Y., Kafkas, E., & Dağ, S. (2026). Protective Effect of Boric Acid Against 3-NPA-Induced Ovarian Damage. BIOLOGICAL TRACE ELEMENT RESEARCH, 204(2), 1008-1021. https://doi.org/10.1007/s12011-025-04725-8

MLA

Başer, Ömer FARUK, Mahmut Karapehlivan, Abdulsamed Kükürt, Ayfer YILDIZ Uysal, Esra Kafkas, and Serpil Dağ. "Protective Effect of Boric Acid Against 3-NPA-Induced Ovarian Damage." BIOLOGICAL TRACE ELEMENT RESEARCH, vol. 204, no. 2, 2026, pp. 1008-1021, doi:10.1007/s12011-025-04725-8.

Chicago

Başer, Ömer FARUK, Mahmut Karapehlivan, Abdulsamed Kükürt, Ayfer YILDIZ Uysal, Esra Kafkas, and Serpil Dağ. 2026. "Protective Effect of Boric Acid Against 3-NPA-Induced Ovarian Damage." BIOLOGICAL TRACE ELEMENT RESEARCH 204 (2): 1008-1021. https://doi.org/10.1007/s12011-025-04725-8

ACM

Ömer FARUK Başer, Mahmut Karapehlivan, Abdulsamed Kükürt, Ayfer YILDIZ Uysal, Esra Kafkas, and Serpil Dağ. 2026. Protective Effect of Boric Acid Against 3-NPA-Induced Ovarian Damage. BIOLOGICAL TRACE ELEMENT RESEARCH 204, 2 (2026), 1008-1021. https://doi.org/10.1007/s12011-025-04725-8

IEEE

[1] Ö. F. Başer, M. Karapehlivan, A. Kükürt, A. Y. Uysal, E. Kafkas, and S. Dağ, "Protective Effect of Boric Acid Against 3-NPA-Induced Ovarian Damage," BIOLOGICAL TRACE ELEMENT RESEARCH, vol. 204, no. 2, pp. 1008-1021, 2026, doi: 10.1007/s12011-025-04725-8.

BibTeX

@article{Başer2026Protective, author = {Başer, Ömer FARUK and Karapehlivan, Mahmut and Kükürt, Abdulsamed and Uysal, Ayfer YILDIZ and Kafkas, Esra and Dağ, Serpil}, title = {Protective Effect of Boric Acid Against 3-NPA-Induced Ovarian Damage}, year = {2026}, journal = {BIOLOGICAL TRACE ELEMENT RESEARCH}, volume = {204}, number = {2}, pages = {1008--1021}, doi = {10.1007/s12011-025-04725-8}, }

Dergi Adı	BIOLOGICAL TRACE ELEMENT RESEARCH
Kısa Adı	BIOL TRACE ELEM RES
Yayıncı	SPRINGERNATURE
Açık Erişim	Evet
ISSN	0163-4984
E-ISSN	1559-0720
Wos Quartile	Q2
Scopus Quartile	Q1
Tarandığı Indeksler	SCIE , Scopus
WoS Kategoriler	BIOCHEMISTRY & MOLECULAR BIOLOGY \| ENDOCRINOLOGY & METABOLISM
Scopus Kategoriler	INORGANIC CHEMISTRY \| BIOCHEMISTRY \| BIOCHEMISTRY (MEDICAL) \| CLINICAL BIOCHEMISTRY \| ENDOCRINOLOGY, DIABETES AND METABOLISM \| MEDICINE (MISCELLANEOUS)