Integrated assessment of brackish water induced deleterious impacts: Analysis of hemato-biochemistry, erythrocytic toxicity, histopathology and oxidative stress biomarkers of mrigal carp
Yazarlar (9)
Ghulam Ali Raza The Islamia University Of Bahawalpur, Pakistan
Riaz Hussain The Islamia University Of Bahawalpur, Pakistan
Abdul Ghaffar The Islamia University Of Bahawalpur, Pakistan
Mudassar Mohiuddin
The Islamia University Of Bahawalpur, Pakistan
The Islamia University Of Bahawalpur, Pakistan
Dr. Öğr. Üyesi Roshan RIAZ Kafkas Üniversitesi, Türkiye
Shah Nawaz Faculty Of Health And Medical Sciences, İngiltere
Doç. Dr. Mükremin ÖLMEZ Kafkas Üniversitesi, Türkiye
Dalia Fouad College Of Sciences, Suudi Arabistan
Promy Virk College Of Sciences, Suudi Arabistan
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Plos One (Q2) | ||
| Dergi ISSN | 1932-6203 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2026 |
| Cilt / Sayı / Sayfa | 21 / 1 / – | DOI | 10.1371/journal.pone.0338381 |
| Makale Linki | https://doi.org/10.1371/journal.pone.0338381 | ||
| UAK Araştırma Alanları |
Sağlık Bilimleri
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| Özet |
| Salinity is recognized as one of the most detrimental abiotic stressors, inducing a range of cellular and biochemical disruptions in both marine and freshwater organisms worldwide. In this study, 84 healthy specimens of mrigal carp (Cirrhinus mrigala) were randomly selected and assigned to four experimental groups (T0, T1, T2, and T3). Each group was maintained under standardized laboratory conditions and exposed to different salinity levels (0, 3, 5, and 7 ppt) in brackish water to evaluate the resulting toxico-physiological responses over 90 days interval. Hematological analysis revealed a significant reduction in erythrocyte count, hemoglobin concentration, hematocrit values, and lymphocyte percentage in salinity-exposed (5, and 7 ppt) fish. In contrast, a notable elevation in total white blood cell (WBC) count and neutrophil population was observed in fish exposed to salinity (5, and 7 ppt) at days 60 and 90 of study. Biochemical assessment of serum parameters demonstrated a marked decline in albumin triglycerides and glucose levels, whereas concentrations of lactate dehydrogenase (LDH), cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatinine, and urea increased significantly in fish at days 60 and 90 of trial subjected to salinity (5, and 7 ppt). A significant elevation in oxidative stress biomarkers was observed in fish exposed to brackish water (5, and 7 ppt), accompanied by a substantial decline in the activity of key antioxidant enzymes, including glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) in erythrocytes. Histopathological examination of visceral … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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| Web of Science | 1 |
| Google Scholar | 1 |