C5-Arylidene Rhodanine Scaffolds from L-Phenylalanine and Core Structures: Synthesis and Anticancer Evaluation
Yazarlar (5)
Doç. Dr. Erbay KALAY Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Şakir AKGÜN Kafkas Üniversitesi, Türkiye
Batuhan Çakmakçı
Kafkas Üniversitesi, Türkiye
Kafkas Üniversitesi, Türkiye
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
Doç. Dr. Alpaslan Bayrakdar Iğdır Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q2) | ||
| Dergi ISSN | 0022-2860 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2026 |
| Cilt / Sayı / Sayfa | 1359 / 1 / – | DOI | 10.1016/j.molstruc.2026.145520 |
| Makale Linki | https://doi.org/10.1016/j.molstruc.2026.145520 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| A series of novel rhodanine derivatives was designed, synthesized, and evaluated for their anticancer potential against human lung (A549) and breast (MCF-7) cancer cell lines. The synthetic approach involved the preparation of (S)-2-(4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid from L-phenylalanine in a one-pot procedure, followed by base-mediated acylation of 4-hydroxybenzaldehyde with various aryl acyl chlorides. Subsequent Knoevenagel condensation of rhodanine and the L-phenylalanine–derived rhodanine analog furnished the target compounds (L-4b–f and 5a–f) in 52–86% yields. Cytotoxic evaluation using the MTT assay revealed that several derivatives displayed greater potency toward MCF-7 cells compared with A549 cells. Among these, compound 5d exhibited dual activity (IC50 = 10.88 µM for MCF-7; 19.12 µM for A549), while 5c was identified as the most active analog in A549 … |
| Anahtar Kelimeler |
| Anticancer activity | Breast cancer | Cytotoxicity | Lung cancer | Rhodanine |
Science Direct
C5-Arylidene Rhodanine Scaffolds from L-Phenylalanine and Core Structures: Synthesis and Anticancer Evaluation
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Google Scholar | 1 |