Design and Synthesis of Polymethoxy Rhodanines as Selective Small-Molecule Candidates for Breast Cancers
Yazarlar (7)
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Gurbet Çelik Turgut Pamukkale Üniversitesi, Türkiye
Doç. Dr. Ayşe Merve Şenol Sağlık Bilimleri Üniversitesi, Türkiye
Pelin Tokalı
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Arş. Gör. Furkan Çakır Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Doç. Dr. Halil Şenol Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Prof. Dr. Alaattin Şen Pamukkale Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q2) | ||
| Dergi ISSN | 0022-2860 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2026 |
| Cilt / Sayı / Sayfa | 1361 / 1 / – | DOI | 10.1016/j.molstruc.2026.145703 |
| Makale Linki | https://doi.org/10.1016/j.molstruc.2026.145703 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Breast cancer remains a major health challenge due to the heterogeneity of tumor subtypes and the limited efficacy of single-target therapeutic approaches. In this study, a new series of polymethoxy rhodanines was designed and synthesized, and their anticancer potential was evaluated against MCF-7 and MDA-MB-231 breast cancer cell lines, together with healthy HEK-293 cell line. Among the tested derivatives, compound 2 emerged as the most promising candidate, exhibiting potent cytotoxic activity against MCF-7 (IC50 = 17.38 ± 2.02 µM) and MDA-MB-231 (IC50 = 27.30 ± 1.04 µM) cells, along with high selectivity indices of 30.8 and 19.6, respectively, compared to HEK-293 cells. To predict the molecular basis of its activity, compound 2 was subjected to computational studies targeting estrogen receptor alpha (ERα) and vascular endothelial growth factor receptor 2 (VEGFR2). Induced-fit docking and … |
| Anahtar Kelimeler |
| Cancer | ERα | Molecular dynamics | Rhodanine | VEGFR2 |
Science Direct
Design and Synthesis of Polymethoxy Rhodanines as Selective Small-Molecule Candidates for Breast Cancers
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 3 |
| Google Scholar | 3 |