Synthesis, multi-target evaluation and DFT analysis of 6-hydroxychromone derived hydrazones with carbonic anhydrase I–II/acetylcholinesterase inhibition and antioxidant activity
Yazarlar (11)
Wajeeha Zareen
Bahauddin Zakariya University, Pakistan
Bahauddin Zakariya University, Pakistan
Nadeem Ahmed
Central South University, Çin
Central South University, Çin
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
Talha Islam
Forman Christian College Lahore, Pakistan
Forman Christian College Lahore, Pakistan
Marıya Al-Rashıda Forman Christian College Lahore, Pakistan
Doç. Dr. Ayşe Merve Şenol Sağlık Bilimleri Üniversitesi, Türkiye
Dr. Öğr. Üyesi Orhan ULUÇAY Kafkas Üniversitesi, Türkiye
Ahmed Mohamed Tawfeek College of Sciences, Suudi Arabistan
Doç. Dr. Parham Taslımı Bartın Üniversitesi, Türkiye
Zahıd Shafıq
Bahauddin Zakariya University, Pakistan
Bahauddin Zakariya University, Pakistan
Mohammad Shahıdul Islam College of Sciences, Suudi Arabistan
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Rsc Advances (Q2) | ||
| Dergi ISSN | 2046-2069 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2026 |
| Cilt / Sayı / Sayfa | 16 / 10 / 8807–8827 | DOI | 10.1039/d5ra10080a |
| Makale Linki | https://doi.org/10.1039/d5ra10080a | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Alzheimer's disease seems to be the result of several tumultuous processes such as cholinergic deficits associated with the abnormal metabolic status and oxidative stress that cannot be controlled effectively by single-target molecules. A complex group of agents capable of combining specific enzyme inhibition with antioxidant protection may be seen as an approach toward neuroprotection. The partial synthesis method led to the creation of a new series of chromone hydrazones (3a–p) from substituted hydrazones and 6-hydroxy-chromone. All the newly obtained hydrazones were assayed for their inhibitory activity against acetylcholinesterase (AchE) and human carbonic anhydrases (CA I and II), and their antioxidant potentials were also studied. The chromone-substituted hydrazones 3c, 3e, and 3f exhibited good inhibitory activity against AChE with IC50 values of 0.82 µM, 0.20 µM, and 1.11 µM, respectively … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |
| Scopus | 3 |
| Google Scholar | 4 |