The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions
Yazarlar (2)
Ahmet Esat Göner
Doç. Dr. Hatice Esra DURAN Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (Q3) | ||
| Dergi ISSN | 0885-4513 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 02-2026 |
| Cilt / Sayı / Sayfa | 73 / 1 / 43–55 | DOI | 10.1002/bab.70003 |
| Makale Linki | https://doi.org/10.1002/bab.70003 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches. Numerous scientists have targeted the polyol pathway as a target for intervention since it includes aldose reductase (ALR2, AR (E.C.1.1.1.21)), a crucial enzyme. Oxidative damage, NADPH depletion, and intracellular sorbitol buildup result from the overactivation of ALR2 brought on by hyperglycemia. Interest in creating novel ALR2 inhibitors (ALR2Is) with enhanced therapeutic characteristics has increased as a result of this circumstance. The amazing biological capabilities of isoxazole molecules led us to look into the biological properties of isoxazole and related compounds. We examined these isoxazoles' binding affinities and interactions in the ALR2 active site … |
| Anahtar Kelimeler |
| aldose reductase | diabetic complications | inhibition | in silico study | isoxazole |
BM Sürdürülebilir Kalkınma Amaçları
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| Web of Science | 2 |
| Google Scholar | 4 |