Synthesis and in Silico Evaluation of Novel Triazolone‐Derived Naphthalene‐2‐Sulfonates, Evaluation of Potential Antiproliferative Agents and Enzyme Inhibitory Activities
Yazarlar (9)
Doç. Dr. Onur AKYILDIRIM Kafkas Üniversitesi, Türkiye
Doç. Dr. Abdülmelik Aras Iğdır Üniversitesi, Türkiye
Öğr. Gör. Ercan Oğuz Iğdır Üniversitesi, Türkiye
Doç. Dr. Alpaslan Bayrakdar Iğdır Üniversitesi, Türkiye
Doç. Dr. Fikret Türkan Iğdır Üniversitesi, Türkiye
Prof. Dr. Murat BEYTUR Kafkas Üniversitesi, Türkiye
Doç. Dr. Hilal MEDETALİBEYOĞLU Kafkas Üniversitesi, Türkiye
Prof. Dr. Ercan Bursal Muş Alparslan Üniversitesi, Türkiye
Prof. Dr. Haydar YÜKSEK Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biotechnology and Applied Biochemistry (Q3) | ||
| Dergi ISSN | 0885-4513 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 02-2026 |
| Cilt / Sayı / Sayfa | 0 / 1 / 1–14 | DOI | 10.1002/bab.70140 |
| Makale Linki | https://doi.org/10.1002/bab.70140 | ||
| UAK Araştırma Alanları |
Organik Kimya
Nanoteknoloji
Teorik Kimya
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| Özet |
| This study reports the synthesis and biological evaluation of four novel N‐acetyl‐derived heterocyclic compounds, namely 2‐((1‐acetyl‐3‐substituted‐5‐oxo‐1,5‐dihydro‐4H‐1,2,4‐triazol‐4‐yl)iminomethyl)‐phenyl‐naphthalene‐2‐sulfonates. The compounds were synthesized via acetylation reactions using acetic anhydride and were fully characterized by IR, 1H NMR, 13C NMR, elemental analysis, and HR‐MS techniques. The anticancer activities of the synthesized compounds were evaluated in the concentration range of 1.563–200 µM against HepG2 (hepatocellular carcinoma) and U87 (glioblastoma) cell lines, showing significant cytotoxic effects. Enzyme inhibition assays demonstrated potent inhibitory activities against α‐glucosidase, α‐amylase, acetylcholinesterase (AChE), and glutathione S‐transferase (GST), with IC50 values ranging from 1.4 to 2.9 µM. Molecular docking studies, performed using DFT … |
| Anahtar Kelimeler |
| cytotoxicity | enzyme inhibition | molecular docking | naphthalene-2-sulfonate | Schiff base |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |