Novel 1,2,4-triazole derivatives: Synthesis, structural characterization, antidiabetic, anticholinergic and phase II detoxification activities, cytotoxic evaluation, and molecular docking studies
Yazarlar (9)
Doç. Dr. Onur AKYILDIRIM Kafkas Üniversitesi, Türkiye
Öğr. Gör. Ercan Oğuz Iğdır Üniversitesi, Türkiye
Doç. Dr. Abdülmelik Aras Iğdır Üniversitesi, Türkiye
Doç. Dr. Adnan Çetin Van Yüzüncü Yıl Üniversitesi, Türkiye
Doç. Dr. Fikret Türkan Iğdır Üniversitesi, Türkiye
Prof. Dr. Ercan Bursal Muş Alparslan Üniversitesi, Türkiye
Doç. Dr. Murat BEYTUR Kafkas Üniversitesi, Türkiye
Doç. Dr. Hilal MEDETALİBEYOĞLU Kafkas Üniversitesi, Türkiye
Prof. Dr. Haydar YÜKSEK Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q2) | ||
| Dergi ISSN | 0022-2860 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 06-2026 |
| Cilt / Sayı / Sayfa | 1363 / 1 / 145749– | DOI | 10.1016/j.molstruc.2026.145749 |
| Makale Linki | https://doi.org/10.1016/j.molstruc.2026.145749 | ||
| UAK Araştırma Alanları |
Organik Kimya
Nanoteknoloji
Teorik Kimya
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| Özet |
| Substituted 1,2,4-triazole derivatives are scientifically important molecules due to their potent biological activities and broad pharmacological application potential. For this purpose, the substituted 1,2,4-triazole-based phenyl naphthalene-2-sulfonates were synthesized, and the structures of the compounds were characterized using IR, 1H-NMR, 13C-NMR, and elemental analysis methods. The biological activities of the 1,2,4-triazole-based naphthalene-2-sulfonates were evaluated for both enzyme inhibition and anticancer effects. The enzyme-inhibitory effects of the 1,2,4-triazole-based naphthalene-2-sulfonates were evaluated against α-glucosidase (α-Gly), α-amylase (α-Amy), glutathione S-transferase (GST), and acetylcholinesterase (AChE). Their IC50 values were found in the range of 1.093±0.450 µM - 3.310±0.689 µM for α-Gly, 1.741±1.223 µM - 2.595±0.901 µM for α-Amy, 1.246±0.370 µM - 2.585±0.320 µM … |
| Anahtar Kelimeler |
| Cyclization | Cytotoxicity | Enzyme inhibition | Heterocycles | Triazole |
Science Direct
Novel 1,2,4-triazole derivatives: Synthesis, structural characterization, antidiabetic, anticholinergic and phase II detoxification activities, cytotoxic evaluation, and molecular docking studies
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 2 |
| Google Scholar | 2 |